2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-107

AChE-IN-107 是一种选择性乙酰胆碱酯酶 (AChE) 抑制剂，其 IC50 为 0.22 μM，Ki 为 0.207 μM。AChE-IN-107 在 10 μM 浓度下对马血清丁酰胆碱酯酶 (BChE) 无抑制作用。AChE-IN-107 对电鳗乙酰胆碱酯酶表现出混合型抑制作用，可同时结合游离酶和酶-底物复合物。AChE-IN-107 具有细胞毒性，能够降低肝癌 HepG2 细胞的存活率。AChE-IN-107 可用于阿尔茨海默病的相关研究。

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AChE-IN-107

AChE-IN-107 Chemical Structure

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AChE-IN-107 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.22 μM and a Ki of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease[1].

IC50 & Target[1]

AChE

0.22 μM (IC50)

AChE

0.207 μM (Ki)

体外研究
(In Vitro)

AChE-IN-107 (compound 22) 能以有利的能量结合人乙酰胆碱酯酶 (hAChE) 的催化活性位点 (CAS)，并与 Trp86、Tyr133 和 Tyr337 产生关键相互作用[1]。
AChE-IN-107 具备优良的 ADMET 性质，包括预测的血脑屏障穿透能力和低肝损伤风险 (I 类)[1]。
AChE-IN-107 (0.005-100.0 μM；作用 48 h) 对 HepG2 细胞表现出中等细胞毒性，其 IC50 为 34.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-107 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Human hepatocellular carcinoma HepG2 cell line
Concentration: 0.005-100.0 μM
Incubation Time: 48 h
Result: Exhibited an IC50 of 34.5 μM for inhibiting HepG2 cell viability, indicating moderate cytotoxicity (1 μM < IC50 < 100 μM).
分子量

257.29

Formula

C13H15N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-107 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-107Cholinesterase (ChE)peripheral anionic sitehepatocellular carcinoma HepG2 cellsTrp86catalytic anionic sitealzheimer's diseaseelectric eel acetylcholinesterasehuman acetylcholinesteraseTyr133Tyr337equine serum butyrylcholinesteraseInhibitorinhibitorinhibit

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产品名称：
AChE-IN-107
目录号：
HY-181161
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