1. Epigenetics
  2. hnRNP
  3. ACI-19278

ACI-19278 是一种 TDP-43 PET 示踪剂,其平均 Kd 为 25 nM。ACI-19278 仅结合病理性 TDP-43 聚集体,不与 Aβ、Tau 等交叉反应。[18F]ACI-19278 成功地通过正电子发射计算机断层扫描对人脑中的 TDP-43 病理进行了可视化。ACI-19278 可用于研究 TDP-43 蛋白病变的活体诊断。

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ACI-19278

ACI-19278 Chemical Structure

CAS No. : 3033951-64-0

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生物活性

ACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. ACI-19278 only binds to pathological TDP-43 aggregates and does not cross-react with Aβ, Tau, etc. [18F]ACI-19278 successfully visualized the TDP-43 pathology in the human brain through positron emission computed tomography. ACI-19278 can be used for in vivo diagnosis of TDP-43 protein lesions[1].

分子量

413.44

Formula

C20H17F2N5OS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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产品名称:
ACI-19278
目录号:
HY-179492
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