Adenosine dialdehyde  (Synonyms: 腺苷二醛)

Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (K_i=3.3 nM)^[1]. Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research^[1][2].

Adenosine dialdehyde 以 1.5 μM 的浓度抑制组织培养物中的 MNB 细胞复制，产生 50% 的抑制作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Adenosine dialdehyde (皮下注射；1.5-2.5 mg/kg；输注 7 天 (微型泵输注)) 显著延长荷瘤小鼠的平均寿命，从稀释剂处理的对照组的 20.9 天增加到 AD 处理的动物的 35.3 天^[3]。
Adenosine dialdehyde (皮下注射；1.5-2.5 mg/kg；两个 7 天的周期穿插在 7 天的无药间隔 (微型泵输注) 中) 延长平均寿命80% 的稀释剂处理对照组 (对照组，21.3 天；AD 处理 38.4 天) 小鼠^[3]。
Adenosine dialdehyde (皮下注射；2-3 mg/kg；输注超过7天 (微泵输注)) 对小鼠无造血毒性，可显著抑制小鼠神经母细胞瘤肿瘤生长，全身毒性小^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

265.23

C₁₀H₁₁N₅O₄

34240-05-6

固体

White to off-white

腺苷二醛；腺嘌呤核苷二醛

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. V Ramakrishnan, et al. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells. Neurochem Int. 1987;10(4):423-31.  [Content Brief]

  [2]. G V Madhavan, et al. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem  [Content Brief]

  [3]. B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48(21):5933-6.  [Content Brief]