2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis PI3K/Akt/mTOR NF-κB Immunology/Inflammation
  3. Antifolate SHMT Apoptosis mTOR Reactive Oxygen Species (ROS) Mitochondrial Metabolism
  4. AGF347

AGF347 是一种强效的多靶点抗叶酸剂 (antifolate)，靶向线粒体 (mitochondria) 中的丝氨酸羟甲基转移酶 (SHMT)2 和胞质中的 SHMT1，并抑制嘌呤从头合成。AGF347 可诱导细胞凋亡 (apoptosis)，抑制 mTOR 信号通路，降低谷胱甘肽 (GSH) 水平，并增加活性氧 (ROS) 的产生。AGF347 可抑制 Cisplatin (HY-17394) 敏感和耐药的上皮性卵巢癌 (EOC) 细胞的增殖。AGF347 在 SKOV3 EOC 异种移植小鼠模型中显示出抗肿瘤活性。AGF347 可用于卵巢癌研究。

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AGF347

AGF347 Chemical Structure

CAS No. : 2294820-23-6

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AGF347 相关抗体

Top Publications Citing Use of Products

查看 SHMT 亚型特异性产品:

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SHMT1 SHMT2

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research[1][2].

IC50 & Target[1][2]

mTOR

 

Human SHMT1

 

SHMT2

 

分子量

473.45

Formula

C22H24FN5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AGF347 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGF3472294820-23-6AGF 347AGF-347AntifolateSHMTApoptosismTORReactive Oxygen Species (ROS)Mitochondrial MetabolismSerine hydroxymethyltransferaseMammalian target of Rapamycinantifolatede novo purine biosynthesismTOR signalingCisplatinepithelial ovarian cancer cellsSKOV3 EOCInhibitorinhibitorinhibit

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