2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related
  4. AHR agonist 10

AHR agonist 10 是一种强效的 AHR 激动剂 (EC50 = 2.01 nM)。AHR agonist 10 能够提高关键 AHR 下游通路靶基因的转录水平，包括 CYP1A1 和 CYP1B1。AHR agonist 10 能够下调 CD36 和 IL-18 的表达水平，并且对正常细胞显示出较低的细胞毒性 (> 40 μM )。AHR agonist 10 可以抑制 CCL5、CCL20、IL-6、IL-8、S100A9、TLR4、TNF-α 和 TNFR1 的表达，表明 AHR agonist 10 通过 AHR 依赖性信号通路有效调节炎症反应。AHR agonist 10 可用于银屑病研究 [1]。

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AHR agonist 10

AHR agonist 10 Chemical Structure

CAS No. : 1191937-43-5

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AHR agonist 10 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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生物活性

AHR agonist 10 is a potent AHR agonist (EC50 = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research[1].

IC50 & Target

IL-6

 

IL-8

 

体外研究
(In Vitro)

AHR agonist 10 (Compound B19) (10 μM, 20 μM, 24 h) 能有效增强 AHR 敲低的 HaCaT 细胞中 CYP1A1 和CYP1B1 的表达水平[1]。
AHR agonist 10 (5 μM) 可以在 Lipopolysaccharides (HY-D1056) (LPS) 诱导的 HaCaT 细胞中抑制 CYP1A1、CYP1B1、CCL5、CCL20、IL-6、IL-8、S100A9、TLR4、TNF-α 和 TNFR1 在 mRNA 水平上的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AHR agonist 10 相关抗体:

RT-PCR[1]

Cell Line: AHR knockdown HaCaT cell
Concentration: 10 μM , 20 μM
Incubation Time: 24 h
Result: Enhanced the expression levels of CYP1A1 and CYP1B1 on the HaCaT cells.
体内研究
(In Vivo)

AHR agonist 10 (1%，局部应用，每日一次，持续 7 天) 抑制了 Imiquimod (HY-B0180) 诱导的小鼠背部银屑病症状的发生和进展，表现为红斑和鳞屑的减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Babl/C mice (7-8 weeks old) were administered topically with Imiquimod (62.5 mg/mouse) on the hair-free back[1].
Dosage: 1%
Administration: Topical application, once daily, 7 days
Result: Exhibited the ability to decrease the thickness of the stratum corneum and stratum spinosum of the skin , ameliorating epidermal hyperplasia.
Downregulated the expression of Ki67 and PCNA.
Mitigated psoriasis-associated epidermal hyperplasia by curbing excessive epidermal cell proliferation.
Enhanced the expression levels of ZO-1 and occludin.
Downregulated the expression levels of IL-17, IL-23, and IL-17F, effectively halting the progression of psoriasis by disrupting the responsible cytokine cascade and subsequent inflammatory response.
Effectively activated the AHR pathway, leading to enhanced expression levels of CYP1A1, CYP1B1, and HSP90.
分子量

284.35

Formula

C18H20O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AHR agonist 10 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AHR agonist 101191937-43-5AHR agonist10AHR agonist-10Aryl Hydrocarbon ReceptorCytochrome P450Interleukin RelatedAhRCYPsILAHR agonistPsoriasisHaCaT CellTapinarofCYP1A1CYP1B1Inhibitorinhibitorinhibit

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