2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. ALK-IN-34

ALK-IN-34 是一种间变性淋巴瘤激酶 (ALK) 抑制剂，其IC50为 0.26 μM。ALK-IN-34 在肺癌细胞和胃腺癌细胞中表现出抗增殖活性。

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ALK-IN-34

ALK-IN-34 Chemical Structure

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ALK-IN-34 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK-IN-34 is an Anaplastic Lymphoma Kinase (ALK) inhibitor with an IC50 of 0.26 μM. ALK-IN-34 demonstrates antiproliferative activity against lung cancer cells and gastric adenocarcinoma cells[1].

体外研究
(In Vitro)

ALK-IN-34 (compound 8c) (1-100 μM；处理 72 小时) 可强效抑制 Karpas 299 细胞 (IC50 = 2.17 μM) 和 H2228 细胞 (IC50 = 6.02 μM) 的增殖，对 A549 细胞和 AGS 细胞的抑制活性较低 [1]。
ALK-IN-34 (10 μM) 对 ALK 表现出更高的选择性，但在 10 μM 浓度下也能显著抑制 EGFR 和 VEGFR2 激酶 [1]。
ALK-IN-34 对 L929 正常细胞的毒性更低 (IC50 = 102.2 μM)，低于对 Karpas 299 癌细胞的毒性，其选择性指数为 47.09[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALK-IN-34 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Karpas 299 (NPM-ALK-positive ALCL), H2228 (EML4-ALK-positive NSCLC), A549 (ALK-negative NSCLC), AGS (gastric adenocarcinoma)
Concentration: 1, 5, 10, 25, 50, 100 μM
Incubation Time: 72 h
Result: Inhibited proliferation of Karpas 299 cells with an IC₅₀ of 2.17 μM, H2228 cells with an IC₅₀ of 6.02 μM, A549 cells with an IC₅₀ of 41 μM, and AGS cells with an IC₅₀ of 45.8 μM.
分子量

379.45

Formula

C25H21N3O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALK-IN-34 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK-IN-34Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246EGFR kinaseCDK2anaplastic large cell lymphomaKarpas 299 cellslung cancer cellsVEGFR2 kinaseH2228 cellsnon-small cell lung cancergastric adenocarcinoma cellsAnaplastic Lymphoma KinaseInhibitorinhibitorinhibit

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产品名称：
ALK-IN-34
目录号：
HY-181113
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