2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GlyT
  4. ALX-5407

ALX-5407 ((R)-NFPS) 是一种选择性、具有口服活性的甘氨酸转运体 GlyT1 抑制剂，IC50 值为 3 nM。ALX-5407 可用于研究 N-methyl-D 天冬氨酸受体功能与精神分裂症。

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ALX-5407

ALX-5407 Chemical Structure

CAS No. : 571147-18-7

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ALX-5407 的其他形式现货产品:

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ALX-5407 相关抗体

Top Publications Citing Use of Products

查看 GlyT 亚型特异性产品:

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GlyT1 GlyT2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALX-5407 ((R)-NFPS) is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
COS-7 IC50
3 nM
Compound: ALX-5407
Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
[PMID: 19013063]
JAR IC50
0.39 nM
Compound: ALX5407
Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
[PMID: 21975065]
T98G IC50
4.8 nM
Compound: ALX-5407
Inhibition of [3H]glycine uptake in human T98G cells
Inhibition of [3H]glycine uptake in human T98G cells
[PMID: 19013063]
体外研究
(In Vitro)

ALX-5407 (0-1 mM) GlyT1- 或 GlyT2- 依赖地抑制甘氨酸转运，阻断大鼠大脑和 QT6-1C 细胞中 [3H] 甘氨酸的摄取，IC50 值为 3 nM[1]。
ALX-5407 (50 nM) 在 QT6-1C 细胞中表现出缓慢的解离动力学[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALX-5407 相关抗体:
体内研究
(In Vivo)

ALX-5407 (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

393.45

Formula

C24H24FNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALX-5407 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALX-5407571147-18-7(R)-NFPSALX5407ALX 5407GlyTGlycine transportersaspartate receptorschizophreniaQT6-1Cdissociation kineticratprefrontal cortexInhibitorinhibitorinhibit

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目录号：
HY-10711
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