2. Membrane Transporter/Ion Channel Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Sodium Channel Apoptosis Reactive Oxygen Species (ROS)
  4. AM-36

AM-36 是一种神经保护剂，具有抗氧化和钠通道 (sodium channel) 阻断的双重作用。AM-36 能够抑制细胞凋亡 (apoptosis) 和 活性氧 (ROS) 的产生。AM-36 可减轻大脑中动脉闭塞的大鼠中的神经元损伤并减少多巴胺 (DA) 的释放。AM-36 可用于炎症和神经系统疾病的研究，如脑卒中。

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AM-36

AM-36 Chemical Structure

CAS No. : 199467-52-2

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AM-36 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM-36 is a neuroprotective agent with combined antioxidant and sodium channel blocking actions. AM-36 can inhibit cell apoptosis and ROS prodiction. AM-36 can reduce neuronal damage and DA release after middle cerebral artery occlusion in rats. AM-36 can be used for the researches of inflammation and neurological disease, such as stroke[1][2][3].

体外研究
(In Vitro)

AM-36 (0.01-10 μM) 可完全抑制 Veratridine (HY-N6691) 诱导的毒性 (IC50 值为 1.5-1.9 μM)，并抑制小脑颗粒细胞的凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AM-36 相关抗体:
体内研究
(In Vivo)

AM-36 (6 mg/kg，腹腔注射，MCAO 后 30-180 分钟) 可减轻大脑中动脉闭塞 (MCAO) 大鼠的神经元损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery occlusion (MCAO) rats[1]
Dosage: 6 mg/kg
Administration: Intraperitoneally injection, 30, 60 and 180 mins after MCAO
Result: Reduced cortical damage and neuronal damage.
Reduced Striatal damage treated with AM-36 at 180 mins.
分子量

459.06

Formula

C27H39ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM-36 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-36199467-52-2AM36AM 36Sodium ChannelApoptosisReactive Oxygen Species (ROS)Na channelsNa+ channelsNeuroprotectiveantioxidantsodium channelapoptosisROSDAmiddle cerebral artery occlusionMCAOstrokeInhibitorinhibitorinhibit

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