AM1172 

AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [³H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC₅₀ values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation^[1][2][3].

AM1172 抑制大鼠皮质神经元和人 CCF-STTG1 星形细胞瘤细胞中的 [³H] 花生四烯酸乙醇胺转运，其 IC₅₀ 值分别为 2.1 μM 和 2.5 μM^[1]。
AM1172 (10-30 μM, 5 min) 显著降低 RBL-2H3 细胞中的 [¹⁴C]AEA 水解，同时减少 [¹⁴C]AEA 摄取^[2]。
AM1172 对 G 蛋白偶联的 CB1 受体 (IC₅₀ = 271 nM) 和 CB2 受体 (IC₅₀ = 189 nM) 显示出适度的亲和力^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

409.60

C₂₇H₃₉NO₂

251908-92-6

液体

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Fegley D, et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8756-61.  [Content Brief]

  [2]. Kaczocha M, et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J Biol Chem. 2006 Apr 7;281(14):9066-75.  [Content Brief]