Amino-PEG3-C2-Azido 

Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)^[1]. Amino-PEG3-C2-Azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Pomalidomide (一种 CRBN 配体，也是一种已知的免疫调节酰亚胺药物 (IMiD))通过三乙二醇 (PEG3) 连接体与 Rucaparib 偶联，得到一种化合物，将其命名为 iRucaparib-TP3(IMiD-Rucaparib 与三唑-PEG3 连接体)。iRucaparib-TP3 可诱导 PARP1 降解^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

218.25

C₈H₁₈N₄O₃

134179-38-7

液体（密度：1.10  g/cm³  ）

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.  [Content Brief]