2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage Apoptosis
  3. Aryl Hydrocarbon Receptor Reactive Oxygen Species (ROS) DNA Alkylator/Crosslinker DNA/RNA Synthesis Caspase Apoptosis HIF/HIF Prolyl-Hydroxylase
  4. Aminoflavone

Aminoflavone 是一种抗肿瘤剂。Aminoflavone 通过激活 AhR-miR-125b-2-3p 轴抑制 ITGA6/SOX2 表达，从而靶向乳腺癌干细胞。Aminoflavone 诱导细胞内 ROS 升高，增加氧化 DNA 损伤标志物 8-oxodG 水平和 DNA-蛋白质交联。Aminoflavone 引起 S 期阻滞，激活 caspase-3/8/9 并诱导凋亡 (apoptosis)。Aminoflavone 以不依赖 AhR 的方式抑制 HIF-1α 表达。Aminoflavone 可用于研究乳腺癌。

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Aminoflavone

Aminoflavone Chemical Structure

CAS No. : 165179-35-1

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Aminoflavone 相关抗体

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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HIF-1α HIF

  • 生物活性

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生物活性

Aminoflavone is an anti-tumor agent. Aminoflavone inhibits the expression of ITGA6/SOX2 by activating the AhR-miR-125b-2-3p axis, thereby targeting breast cancer stem cells. Aminoflavone induces an increase in intracellular ROS, increases the level of oxidative DNA damage marker 8-oxodG and DNA-protein cross-links. Aminoflavone causes S-phase arrest, activates caspase-3/8/9 and induces apoptosis (apoptosis). Aminoflavone inhibits HIF-1α expression in a manner independent of AhR. Aminoflavone can be used for the study of breast cancer[1][2][3].

分子量

320.27

Formula

C16H11F3N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aminoflavone 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminoflavone165179-35-1NSC-686288NSC686288NSC 686288Aryl Hydrocarbon ReceptorReactive Oxygen Species (ROS)DNA Alkylator/CrosslinkerDNA/RNA SynthesisCaspaseApoptosisHIF/HIF Prolyl-HydroxylaseAhRHypoxia-inducible factorsHIFsHIF-PHmiR-125b-2-3pbreast cancer stem cellsoxidative DNA damagereactive oxygen speciesHIF-1α inhibitionAhR-independent pathwayInhibitorinhibitorinhibit

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