1. Anti-infection
  2. SARS-CoV
  3. Amubarvimab

Amubarvimab  (Synonyms: 安巴韦单抗; BRII-196)

目录号: HY-P99435 纯度: 95.00%
COA 技术支持

Amubarvimab (BRII-196) 是一种人 IgG1 mAb,可结合刺突蛋白受体结合域 (RBD) 上的非竞争表位,KD 为 5.88 nM。Amubarvimab 可有效中和 SARS-CoV-2 变异体。

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CAS No. : 2509447-07-6

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规格 价格 是否有货 数量
1 mg ¥3500
In-stock
5 mg 现货 询价
10 mg   询价  
50 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants[1][2].

同型

Human IgG4 kappa

推荐同型对照抗体
反应种属

Virus

IC50 & Target

Severe acute respiratory syndrome coronavirus 2

体外研究
(In Vitro)

Amubarvimab 对野生型 SARS-CoV-2 具有特异性活性,并且与其他冠状病毒无交叉反应[1]
Amubarvimab 结合两个区域,跨越受体结合基序 (RBM) 中的氨基酸 453-505 和 RBD 核心区域中的氨基酸残基 403-421[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Amubarvimab (10-50 mg/kg; i.p.) 与 Romusevimab 联合给药可显着降低 SARS-CoV-2 感染的叙利亚金仓鼠肺部病毒载量,并减轻肺部病变[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

143.84 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

安巴韦单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Amubarvimab
目录号:
HY-P99435
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