2. Immunology/Inflammation TGF-beta/Smad Stem Cell/Wnt
  3. CTLA-4 TGF-beta/Smad
  4. AN02

AN02 是一种 Curcumin (HY-N0005) 的衍生物。AN02 抑制卵巢癌细胞的增殖和克隆形成、迁移和侵袭。AN02 剂量依赖性地上调 APC 表达，并通过 SMAD4 介导了 CTLA-4 的降解。AN02 在小异种移植模型中显著抑制了肿瘤生长并逆转肿瘤免疫抑制微环境。AN02 与 Ipilimumab (HY-P9901) 联合可增加疗效，抑制上皮-间质转化。AN02 可用于研究卵巢癌。

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AN02

AN02 Chemical Structure

CAS No. : 1246964-08-8

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AN02 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.39 μM
Compound: 470
Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
MDA-MB-231 IC50
0.39 μM
Compound: 470
Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
MDA-MB-231 IC50
1.6 μM
Compound: A2
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 38746900]
MDA-MB-468 IC50
0.39 μM
Compound: 470
Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
MG-63 IC50
0.39 μM
Compound: 470
Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
MV4-11 IC50
0.39 μM
Compound: 470
Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
NCI-H23 IC50
0.39 μM
Compound: 470
Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
NCI-H441 IC50
5 μM
Compound: 3
Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs
Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs
[PMID: 20638855]
分子量

344.23

Formula

C19H15Cl2NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AN02 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN021246964-08-8AN 02AN-02CTLA-4TGF-beta/SmadCytotoxic T-lymphocyte-associated protein 4CD152Transforming growth factor betacurcumin derivativeovarian cancerAPC-SMAD4-CTLA-4 axisproliferation inhibitionubiquitinationimmune checkpointEMTxenograft modelInhibitorinhibitorinhibit

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