2. Apoptosis
  3. Apoptosis
  4. ANT1034

ANT1034 是人源化抗 CD52 抗体。ANT1034 介导抗体依赖性和补体依赖性细胞毒性，当被交联或在交联抗体存在时诱导凋亡 (Apoptosis)。ANT1034 在 SCID CD52 肿瘤异种移植模型中可延长生存期。ANT1034 可用于 B 细胞恶性肿瘤的研究。

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ANT1034

ANT1034 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

ANT1034 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ANT1034 is humanized anti-CD52 antibody. ANT1034 directs antibody dependent and complement dependent cell cytotoxicity, induces Apoptosis when cross-linked or in the presence of a cross-linking antibody. ANT1034 leads to increased survival in a SCID CD52 tumour xenograft model. ANT1034 can be used for the research of B cell malignancies[1].

反应种属

Human
IC50 & Target

CD52
体外研究
(In Vitro)

在存在交联抗体的情况下，ANT1034 (100 μg/ml；72 小时) 在直接诱导 REH++ 细胞死亡 (凋亡/坏死) 方面比 Alemtuzumab (HY-P9948) 更有效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ANT1034 相关抗体:
体内研究
(In Vivo)

ANT1034 (1-10 mg/kg；腹腔注射；隔日一次，共 7 次给药) 可提高荷 Raji 伯基特淋巴瘤异种移植物的雌性 Fox Chase SCID 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fox Chase SCID mice (female, 8 per group, injected with 1×10⁶ Raji++ cells via tail-vein injection)[1]
Dosage: 1, 10 mg/kg
Administration: i.p.; once daily on alternate days; 7 doses
Result: Increased mouse survival compared to alemtuzumab at 10 mg/kg; Showed superior survival enhancement even at the lower 1 mg/kg dose relative to alemtuzumab
基因 ID

1043  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ANT1034 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANT1034ANT 1034ANT-1034ApoptosisCD4? T cell proliferationRaji Burkitt lymphoma xenograftapoptosisb cell malignanciesSCID mouse/human CD52 tumour xenograft modelcomplement dependent cell cytotoxicityT cell proliferationREH++ cellscancerFox Chase SCID miceantibody dependent cell cytotoxicitycrosslinking antibodyhuman peripheral blood mononuclear cellsalemtuzumabCD52Inhibitorinhibitorinhibit

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产品名称：
ANT1034
目录号：
HY-P991935
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