2. Immunology/Inflammation
  3. NO Synthase
  4. Anti-inflammatory agent 18

Anti-inflammatory agent 18 (化合物 3b) 显示出 NO 抑制活性，其 IC50 为 15.94 μM。Anti-inflammatory agent 18 可抑制 HMGB1 诱导的后期炎症反应。Anti-inflammatory agent 18 可用于后期炎症疾病的研究，如 COVID-19、败血症等。

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Anti-inflammatory agent 18

Anti-inflammatory agent 18 Chemical Structure

CAS No. : 2873386-66-2

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Anti-inflammatory agent 18 相关抗体

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生物活性

Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC50 of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc[1].

IC50 & Target

IC50: 15.94 μM (NO)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
15.94 μM
Compound: 3b
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 34800877]
分子量

506.71

Formula

C30H50O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 18 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 182873386-66-2NO SynthaseNitric oxide synthasesNOSRAW 264.7 cellsPentacyclic triterpenesPTsBiotransformationHigh mobility group box-1 proteinHMGB1Anti-inflammatory activityStreptomyces olivaceus CICC 236283,4-seco-triterpenesCOVID-19sepsisInhibitorinhibitorinhibit

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