2. Immunology/Inflammation
  3. LAG-3
  4. Anti-Mouse FGL-1 Antibody (177R4)

Anti-Mouse FGL-1 Antibody (177R4) 

目录号: HY-P990243
技术支持

Anti-Mouse FGL-1 Antibody (177R4) 是一种抗小鼠 FGL-1 IgG2a 单克隆抗体。Anti-Mouse FGL-1 Antibody (177R4) 可增加 CD8+ T 细胞浸润。Anti-Mouse FGL-1 Antibody (177R4) 通过阻断 FGL1 增强抗肿瘤免疫效果。Anti-Mouse FGL-1 Antibody (177R4) 可用于研究癌症，如肺癌和膀胱癌。

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Anti-Mouse FGL-1 Antibody (177R4)

Anti-Mouse FGL-1 Antibody (177R4) Chemical Structure

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Anti-Mouse FGL-1 Antibody (177R4) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1 IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8+ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer[1][2].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

FGL-1
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse FGL-1 Antibody (177R4) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse FGL-1 Antibody (177R4) (100 μg，腹腔注射，在第 1、3、6、12、15 和 18 天) 与 PD-1 单克隆抗体联合显著抑制携带 Lewis 肺癌 (LLC) 肿瘤的 C57BL/6J 小鼠的肿瘤生长[1]。
Anti-Mouse FGL-1 Antibody (177R4) (100 μg，腹腔注射，在第 6、10、14 和 18 天) 与 PD-1 单克隆抗体联合显著抑制携带 MB49 肿瘤的雌性 C57BL/6J 小鼠的肿瘤生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×106 LLC cells injected C57BL/6J mice (4-6 weeks)[1]
Dosage: 100 μg, combined with PD-1 mAb (100 μg)
Administration: Intraperitoneal injection (i.p.), on day 1, 3, 6, 12, 15 and 18
Result: Significantly inhibited tumor volume.
Increased CD8+ T cell infiltration within the tumor.
Increased the expression of IFN-γ, TNF-α, and Perforin.
Reduced Ki67 positive cells.
Animal Model: 1×105 MB49 cells injected female C57BL/6J mice (6-8 weeks)[2]
Dosage: 100 μg, combined with PD-1 mAb (100 μg)
Administration: Intraperitoneal injection (i.p.), on day 6, 10, 14 and 18
Result: Significantly inhibited tumor volume and weight.
Significantly increased infiltration of CD8 T cells.
基因 ID

234199  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse FGL-1 Antibody (177R4) 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse FGL-1 Antibody (177R4)LAG-3Lymphocyte activation gene-3CD223FGL-1T cellCD8LLCMB49Inhibitorinhibitorinhibit

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