2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Anti-Mouse OX40/CD134 Antibody (OX-86)

Anti-Mouse OX40/CD134 Antibody (OX-86) 

目录号: HY-P990115
技术支持

Anti-Mouse OX40/CD134 Antibody (OX-86) 是一种抗小鼠 OX40/CD134 IgG1 单克隆抗体。Anti-Mouse OX40/CD134 Antibody (OX-86) 可以增强 CD8+ T 细胞的抗肿瘤功能。Anti-Mouse OX40/CD134 Antibody (OX-86) 能够逆转免疫抑制，增强抗原呈递和 T 细胞激活。Anti-Mouse OX40/CD134 Antibody (OX-86) 可用于研究癌症如乳头状瘤和白血病。

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1 mg ￥630
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5 mg ￥2200
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10 mg ￥3500
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Anti-Mouse OX40/CD134 Antibody (OX-86) 相关抗体

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OX2 Receptor OX1 Receptor

  • 生物活性

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  • 参考文献

生物活性

Anti-Mouse OX40/CD134 Antibody (OX-86) is an anti-mouse OX40/CD134 IgG1 monoclonal antibody. Anti-Mouse OX40/CD134 Antibody (OX-86) can enhance the anti-tumor function of CD8+ T cells. Anti-Mouse OX40/CD134 Antibody (OX-86) can reverse immune suppression, enhance antigen presentation and T cell activation. Anti-Mouse OX40/CD134 Antibody (OX-86) can be used for research on cancer such as papilloma and leukemia[1][2][3][4].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

OX40/CD134
体外研究
(In Vitro)

Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg/mL，5-7 天) 上调 DCs 的活化标志物 (CD40 和 CD86)，并降低 SB28-OVA 和 EG7-OVA 细胞中 PD-L1 的表达[3]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (10 µg/mL，1 小时) 显著增强了肿瘤浸润淋巴细胞 (TIL) 诱导的肿瘤细胞凋亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse OX40/CD134 Antibody (OX-86) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg，腹腔注射，每周两次) 对携带 TC-1 肿瘤的雌性 C57BL/6 小鼠的肿瘤生长具有有限的抑制作用[1]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (10 mg/kg，腹腔注射，每周一次，2 剂) 与 PEG-MTAP 联合使用可显著抑制携带 L1210 肿瘤的 DBA/2 小鼠的肿瘤生长[2]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (200 µg，腹腔注射，在第 4、7 和 10 天) 显著抑制携带 SB28-OVA 或 EG7-OVA 肿瘤的雌性 C57BL/6 小鼠的肿瘤生长[3]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg，腹腔注射，每周两次，持续 2 周) 可延缓携带 MC38 肿瘤的 C57BL/6 小鼠的肿瘤生长并增强 CD8+ T 细胞功能[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×105 TC-1 cells injected female C57BL/6 mice (6-8 weeks)[1]
Dosage: 100 µg
Administration: Intraperitoneal injection (i.p.), twice a week
Result: Had a weak inhibitory effect on tumor growth.
Animal Model: 5×104 L1210 cells injected DBA/2 mice (6-8 weeks)[2]
Dosage: 10 mg/kg, combined with PEG-MTAP (50 mg/kg, s.c., 3 times a week, for 5 dose)
Administration: Intraperitoneal injection (i.p.), once a week, for 2 dose
Result: Significantly inhibited tumor volume.
Animal Model: 1600 SB28-OVA cells or 25000 EG7-OVA cells injected female C57BL/6 mice (6-8 weeks)[3]
Dosage: 200 µg
Administration: Intraperitoneal injection (i.p.), on day 4, 7 and 10
Result: Extended the survival period of mice (median survival period extended from 26 days to 31 days).
Reduced the proportion of Tregs and increased the number of memory T cells.
Animal Model: C57BL/6 mice bearing MC38/gp100 tumors[4]
Dosage: 100 µg
Administration: Intraperitoneal injection (i.p.), twice a week, for 2 weeks
Result: Delayed tumor growth.
Enhanced CD8+ T cell function.
基因 ID

22163  [NCBI]

Accession
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C
Biological Activity
  • Immobilized Mouse OX40 Protein, His Tag can bind Anti-Mouse OX40/CD134 Antibody (OX-86). The EC50 for this effect is 171 ng/mL.
纯度 & 产品资料
参考文献

Anti-Mouse OX40/CD134 Antibody (OX-86) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse OX40/CD134 Antibody (OX-86)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorOX40/CD134TC-1L1210CD8T cellsSB28EG7MC38Inhibitorinhibitorinhibit

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