2. Anti-infection
  3. Bacterial
  4. Anti-virulence factor-IN-3

Anti-virulence factor-IN-3 (Compound 21) 是一种共价 β-氨基砜类炭疽水肿因子 (EF) 抑制剂，其 Ki 为 0.44 μM。Anti-virulence factor-IN-3 生成活性乙烯砜中间体，与 EF 活性中心的 Lys 残基形成不可逆共价键，永久抑制 EF 的腺苷酸环化酶活性。Anti-virulence factor-IN-3 有效抑制 EF 诱导的 cAMP 产生，EC50 为 0.15 μM。Anti-virulence factor-IN-3 可用于研究炭疽感染。

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Anti-virulence factor-IN-3

Anti-virulence factor-IN-3 Chemical Structure

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Anti-virulence factor-IN-3 相关抗体

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生物活性

Anti-virulence factor-IN-3 (Compound 21) is a covalent β-aminosulfinyl type anthrax edema factor (EF) inhibitor, with a Ki value of 0.44 μM. Anti-virulence factor-IN-3 generates an active ethylene sulfinyl intermediate, which forms an irreversible covalent bond with the Lys residue at the active center of EF, permanently inhibiting the adenylate cyclase activity of EF. Anti-virulence factor-IN-3 effectively inhibits the cAMP production induced by EF, with an EC50 value of 0.15 μM. Anti-virulence factor-IN-3 can be used for research on anthrax Infection[1].

分子量

563.73

Formula

C29H33N5O3S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-virulence factor-IN-3 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-virulence factor-IN-3BacterialAnthrax edema factorEnzyme-activated substrate inhibitionCovalent inhibitorVirulence factorAdenylate cyclaseβ-aminosulfonecAMP inhibitionBacterial toxinInhibitorinhibitorinhibit

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