2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Bacterial Reactive Oxygen Species (ROS) Apoptosis
  4. Antibacterial agent 292

Antibacterial agent 292 是一种 3-吡唑基吲哚衍生物。Antibacterial agent 292 是一种抗菌剂。Antibacterial agent 292 对水稻黄单胞菌稻致病变种 (Xanthomonas oryzae pv oryzae, Xoo) 和地毯草黄单胞菌柑橘致病变种 (Xanthomonas axonopodis pv citri, Xac) 表现出强效抑制活性，其 EC50 值分别为 2.54 μg/mL 和 3.49 μg/mL。Antibacterial agent 292 能够抑制生物膜的形成、细菌的运动性以及胞外多糖的产生，诱导形态改变并促进 ROS 的积累，最终引发细菌凋亡 (apoptosis)。Antibacterial agent 292 会下调与 VI 型分泌系统 (T6SS) 相关的基因表达。Antibacterial agent 292 可用于水稻白叶枯病和柑橘溃疡病的防治

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Antibacterial agent 292

Antibacterial agent 292 Chemical Structure

CAS No. : 3065015-86-0

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Antibacterial agent 292 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 292 is a 3-pyrazolylindole derivative. Antibacterial agent 292 is an anti-bacterial agent. Antibacterial agent 292 shows potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 and 3.49 μg/mL. Antibacterial agent 292 can suppress biofilm formation, bacterial motility, and extracellular polysaccharide production, induce morphological alterations and promote ROS accumulation, ultimately triggers bacterial apoptosis. Antibacterial agent 292 down-regulates the expression of genes associated with the type VI secretion system (T6SS). Antibacterial agent 292 can be used in rice bacterial blight and citrus canker[1].

体外研究
(In Vitro)

Antibacterial agent 292 (Compound P16) (3.125-25 μg/mL) 可抑制 Xoo 和 Xac 细胞的生长[1]。
Antibacterial agent 292 (3.125-12.5 μg/mL) 能增加 Xoo 和 Xac 细胞中活性氧的积累并诱导其凋亡[1]。
Antibacterial agent 292 (3.125-50 μg/mL) 可抑制 Xoo 和 Xac 细胞的生物膜形成、胞外多糖含量及运动能力[1]。
Antibacterial agent 292 可降低 Xoo 细胞中 VI 型分泌系统 (T6SS) 中 vgrG、hcp 和 clpV 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 292 相关抗体:
分子量

448.95

Formula

C24H25ClN6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 292 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antibacterial agent 2923065015-86-0Antibacterial agent292Antibacterial agent-292BacterialReactive Oxygen Species (ROS)Apoptosisanti-bacterialXanthomonas oryzae pv oryzaeXanthomonas axonopodis pv citriROSapoptosisT6SSricebacterial blightcitrus cankerInhibitorinhibitorinhibit

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