2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 110

Anticancer agent 110 是一种抗癌剂，具有体外抗癌活性以及对出色抗白血病效力。Anticancer agent 110 对 K-562 系慢性粒细胞白血病细胞在纳摩尔浓度下具有高细胞毒性。Anticancer agent 110 引起 DNA 损伤，并导致细胞凋亡 (apoptosis)。

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Anticancer agent 110

Anticancer agent 110 Chemical Structure

CAS No. : 887349-03-3

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Anticancer agent 110 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CAKI-1 IC50
772 nM
Compound: 3d
Inhibition of cell growth in human CAKI-1 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human CAKI-1 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
HCT-15 IC50
347 nM
Compound: 3d
Inhibition of cell growth in human HCT-15 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human HCT-15 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
HaCaT IC50
> 100 μM
Compound: 3d
Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 36809707]
J774.2 IC50
70.67 μM
Compound: 3d
Antiproliferative activity against J774.2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against J774.2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 36809707]
K562 IC50
0.7 μM
Compound: 3d
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 36809707]
K562 IC50
56.4 nM
Compound: 3d
Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
KM12 IC50
927 nM
Compound: 3d
Inhibition of cell growth in human KM12 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human KM12 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
LOX IMVI IC50
206 nM
Compound: 3d
Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
M14 IC50
261 nM
Compound: 3d
Inhibition of cell growth in human M14 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human M14 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
NCI-H460 IC50
993 nM
Compound: 3d
Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
NIH3T3 IC50
> 100 μM
Compound: 3d
Antiproliferative activity against NIH3T3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against NIH3T3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 36809707]
SW-620 IC50
118 nM
Compound: 3d
Inhibition of cell growth in human SW-620 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human SW-620 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
T47D IC50
896 nM
Compound: 3d
Inhibition of cell growth in human T47D cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human T47D cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
UACC-62 IC50
56.9 nM
Compound: 3d
Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB assay
Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB assay
[PMID: 36809707]
体外研究
(In Vitro)

Anticancer agent 110 (化合物 3d) (0.01 μM-100 μM) 抑制白血病 K-562 细胞，IC50 为 0.7 μM[1]。
Anticancer agent 110 (70 nM、700 nM；24 h) 在 K-562 细胞中引起更高水平的 DNA 损伤[1]。
Anticancer agent 110 (70 nM、700 nM；24 h) 诱导白血病细胞形态发生促凋亡变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 110 相关抗体:
分子量

380.40

Formula

C18H13FN6OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 110 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 110887349-03-3Anticancer agent110Anticancer agent-110Apoptosisanticanceranti-leukemiaK-562DNA damageapoptosisInhibitorinhibitorinhibit

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