2. Apoptosis
  3. RIP kinase
  4. Anticancer agent 284

Anticancer agent 284 对骨肉瘤细胞系 (Hos)、非小细胞肺癌细胞系 (A549) 和结肠癌细胞系 (HCT-116) 均具有细胞毒性。Anticancer agent 284 可使 A549 细胞中的 pRIPK3 激酶浓度降低至2.97 pg/mL。Anticancer agent 284 可用于癌症研究。

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Anticancer agent 284

Anticancer agent 284 Chemical Structure

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Anticancer agent 284 相关抗体

Top Publications Citing Use of Products

查看 RIP kinase 亚型特异性产品:

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RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 284 exhibits cytotoxicity against osteosarcoma cell line (Hos), non-small cell lung cancer cell line (A549), and colon cancer cell line (HCT-116). Anticancer agent 284 can impact the pRIPK3 kinase concentration in the A549 (2.97 pg/mL). Anticancer agent 284 can be used for the study of cancer[1].

体外研究
(In Vitro)

Anticancer agent 284 (Compound 4) 对所有测试的细胞系均具有细胞毒性，其 IC50 活性顺序为 HCT-116 (7.3 µM) > A549 (20.4 µM) > Hos (39.9 µM)[1]。
Anticancer agent 284 对 A549 细胞中的 pRIPK3 有轻微抑制作用 (2.97 pg/mL)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 284 相关抗体:

ELISA Assay[1]

Cell Line: A549 human lung cancer cells
Concentration: 20.4 μM (treat with the IC50 concentration of the active compound)
Incubation Time: 24 h
Result: Impacted the pRIPK3 kinase concentration in the A549 (2.97 pg/mL).
分子量

487.57

Formula

C26H25N5O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 284 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 284Anticancer agent284Anticancer agent-284RIP kinaseReceptor-interacting protein kinasesRIPKN-benzyl-4-thiazoloneN-benzylthiazoleN-phenylpyrazoloneEdaravoneMTTRIPK3Inhibitorinhibitorinhibit

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HY-178937
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