2. Anti-infection Stem Cell/Wnt TGF-beta/Smad GPCR/G Protein MAPK/ERK Pathway
  3. Fungal PKA Ras
  4. Antifungal agent 140

Antifungal agent 140 (compound 5p) 是一种强效广谱抗真菌 (antifungal) 剂。Antifungal agent 140 通过靶向 Ras/cAMP/PKA 通路抑制菌丝形成和麦角甾醇生物合成途径发挥双重作用。在系统性念珠菌病小鼠模型中，Antifungal agent 140 可提高小鼠存活率，降低肾脏真菌负荷，并增强宿主免疫反应。Antifungal agent 140 可用于耐药真菌感染的研究。

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Antifungal agent 140

Antifungal agent 140 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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Antifungal agent 140 相关抗体

Top Publications Citing Use of Products

查看 PKA 亚型特异性产品:

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PKA PKAR PKACα

查看 Ras 亚型特异性产品:

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifungal agent 140 (compound 5p) is a potent antifungal agent with broad-spectrum antifungal activity. Antifungal agent 140 exerts a dual mechanism by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and the ergosterol biosynthesis pathway. Antifungal agent 140 enhances survival, reduces fungal load in the kidneys, and strengthens host immune responses in a murine model of systemic candidiasis. Antifungal agent 140 can be used for research of resistant fungal infections[1].

分子量

520.57

Formula

C28H30F2N6O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antifungal agent 140 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 140Antifungal agent140Antifungal agent-140FungalPKARasProtein kinase AantifungalRas/cAMP/PKAhyphal formationergosterol biosynthesissystemic candidiasisInhibitorinhibitorinhibit

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