2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-13

Antileishmanial agent-13 是一种喹啉-靛蓝杂交物，可作为抗利什曼病试剂，抑制 L. Major Leishmania 株系。Antileishmanial agent-13 通过抗叶酸机制获得其抗利什曼病活性。Antileishmanial agent-13 对前鞭毛体和无鞭毛体均具有较强的抑制作用，IC50 分别为 0.604 μM 和 0.508 μM。

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Antileishmanial agent-13

Antileishmanial agent-13 Chemical Structure

CAS No. : 853725-86-7

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Antileishmanial agent-13 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively[1].

IC50 & Target

Leishmania

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero CC50
155.8 μM
Compound: 4e
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
[PMID: 36493614]
体外研究
(In Vitro)

Antileishmanial agent-13 (compound 4e) shows promising in vitro activity against the promastigote superior to Miltefosine.html" class="link-product" target="_blank">Miltefosine (HY-13685) (IC50=7.8976 µM)[1].
Antileishmanial agent-13 (2 μM; 48 h) shows antileishmanial activity mostly attributing to the anti-folate mechanism, via inhibiting DHFR-TS and PTR1[1].
Antileishmanial agent-13 (0-100 μM; 72 h) has low cytotoxicity against African green monkey kidney cells (VERO cells) with CC50 value of 155.8 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antileishmanial agent-13 相关抗体:
分子量

401.64

Formula

C17H10BrClN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antileishmanial agent-13 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-13853725-86-7Antileishmanial agent13Antileishmanial agent 13Parasitequinoline-isatin hybridL. Major LeishmaniapromastigoteamastigoteInhibitorinhibitorinhibit

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