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  4. Antitrypanosomal agent 10

Antitrypanosomal agent 10 是一种抗锥虫剂，可抑制克氏锥虫 (Trypanosoma cruzi)，IC50 为 0.28 μM。

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Antitrypanosomal agent 10

Antitrypanosomal agent 10 Chemical Structure

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Antitrypanosomal agent 10 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC50 of 0.28 μM[1].

IC50 & Target

Trypanosoma

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 CC50
2.4 μM
Compound: 46
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
[PMID: 36459758]
L6 CC50
50 μM
Compound: 46
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
[PMID: 36459758]
MRC5 CC50
> 64 μM
Compound: 46
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
[PMID: 36459758]
NIH3T3 CC50
> 40 μM
Compound: 46
Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
[PMID: 36459758]
Peritoneal macrophage CC50
4 μM
Compound: 46
Cytotoxicity against primary peritoneal mouse macrophages assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
Cytotoxicity against primary peritoneal mouse macrophages assessed as reduction in cell viability measured after 24 hrs by colorimetric assay
[PMID: 36459758]
体外研究
(In Vitro)

Antitrypanosomal agent 10 (compound 46) has good selectivity over mammalian cells, acceptable mouse liver microsome (MLM) clearance and lipophilicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitrypanosomal agent 10 相关抗体:
分子量

413.28

Formula

C17H9F6N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitrypanosomal agent 10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitrypanosomal agent 10Antitrypanosomal agent10Antitrypanosomal agent-10Parasiteantitrypanosomal activityTrypanosoma cruzilipophilicityInhibitorinhibitorinhibit

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产品名称：
Antitrypanosomal agent 10
目录号：
HY-151942
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