2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-135

Antitumor agent-135 (Compound 13) 是一种有效的抗肿瘤药物。Antitumor agent-135 诱导细胞凋亡，对 NSCLC 细胞株 (A549、H460、PC-9 和 PC-9/GR) 的 IC50 分别为 3.79、10.55、1.14 和 4.14 μM。

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Antitumor agent-135

Antitumor agent-135 Chemical Structure

CAS No. : 2922110-00-5

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Antitumor agent-135 相关抗体

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  • 生物活性

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生物活性

Antitumor agent-135 (Compound 13) is a potent antitumor agent. Antitumor agent-135 induces cell apoptosis, with IC50s of 3.79 , 10.55, 1.14, and 4.14 μM for NSCLC cell lines (A549, H460, PC-9, and PC-9/GR)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.79 μM
Compound: 13
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38244939]
NCI-H460 IC50
10.55 μM
Compound: 13
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38244939]
PC-9 IC50
1.14 μM
Compound: 13
Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38244939]
分子量

1332.42

Formula

C68H77N13O16
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-135 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antitumor agent-1352922110-00-5Antitumor agent135Antitumor agent 135ApoptosisantitumorapoptosisA549H460PC-9PC-9/GRInhibitorinhibitorinhibit

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