2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. AP2238

AP2238 是一种双功能的乙酰胆碱酯酶 (AChE) 抑制剂，对人 AChE (HuAChE) 和丁酰胆碱酯酶 (BuChE) 的 Ki 为 21.7 和 48.9 μM。AP2238 阻断 AChE 外周位点与 Aβ 的促纤维化相互作用，可抑制 Aβ 聚集。AP2238 可用于研究阿尔茨海默症。

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AP2238

AP2238 Chemical Structure

CAS No. : 553681-56-4

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AP2238 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with Ki values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

hAChE

21.7 μM (Ki)

hBCHE

48.9 μM (Ki)

分子量

415.48

Formula

C26H25NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AP2238 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP2238553681-56-4AP 2238AP-2238Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaacetylcholinesterase inhibitordual-binding siteAβ aggregationAlzheimer's diseasecoumarin derivativeperipheral anionic sitemolecular dockingInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-119292
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