2. Apoptosis MAPK/ERK Pathway Anti-infection
  3. Apoptosis p38 MAPK Parasite
  4. Apoptosis inducer 53

Apoptosis inducer 53 是一种凋亡 (apoptosis) 诱导剂。Apoptosis inducer 53 能够抑制人类肿瘤细胞系 (A549、HeLa、SW1573、T-47D、WiDr) 的增殖，其 GI50 值为 2.5-9.1 μM。Apoptosis inducer 53 可以诱导癌细胞凋亡并减少集落形成。Apoptosis inducer 53 能够激活 p38α MAPK 信号通路，并发挥抗炎作用。Apoptosis inducer 53 还具有抗杜氏利什曼原虫 (Leishmania donovani) 活性。Apoptosis inducer 53 可用于癌症、感染和炎症的研究。

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Apoptosis inducer 53

Apoptosis inducer 53 Chemical Structure

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Apoptosis inducer 53 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 53 is an apoptosis inducer. Apoptosis inducer 53 can inhibit proliferation of human tumor cell lines (A549, HeLa, SW1573, T-47D, WiDr) with GI50 values of 2.5-9.1 μM. Apoptosis inducer 53 can induce cancer cells apoptosis and reduce colony formation. Apoptosis inducer 53 can activate p38α MAPK signaling and exerts anti-inflammatory effect. Apoptosis inducer 53 also shows anti-Leishmania donovani activity. Apoptosis inducer 53 can be used for the researches of cancer, infection and inflammation[1].

体外研究
(In Vitro)

Apoptosis inducer 53 (Compound 24) (2.5-9.1 μM) 可抑制人肿瘤细胞系 (A549、HeLa、SW1573、T-47D、WiDr) 的增殖，其 GI50 值分别为 3.7 μM、2.5 μM、3.7 μM、9.1 μM 和 4.9 μM[1]。
Apoptosis inducer 53 (25 μM, 20 h) 可在 HeLa 细胞中诱导典型的凋亡表型[1]。
Apoptosis inducer 53 (7.5-12.5 μM, 24 h or 0.83-2.5 μM, 7 days) 以剂量依赖性方式减少 HeLa 细胞的集落形成[1]。
Apoptosis inducer 53 可抑制 THP-1 分化的巨噬细胞中杜氏利什曼原虫无鞭毛体的生长，其 IC50 为 2.59 μM[1]。
Apoptosis inducer 53 (10 μM, 24 h) 通过激活 p38α MAPK 信号，可抑制 LPS (HY-D1056) 刺激的 BV.2 小胶质细胞中 NLRP3、Caspase-1 和 IL-1β 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 53 相关抗体:

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 25 μM
Incubation Time: 20 h
Result: Showed cell shrinkage and content fragmentation.
Caused nuclear condensation and fragmentation and showed positive Annexin V staining.
Did not induce ROS production, disrupt mitochondrial membrane potential, or affect cell microtubule structure.
分子量

531.65

Formula

C26H39F2NO6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 53 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 53Apoptosis inducer53Apoptosis inducer-53Apoptosisp38 MAPKParasiteTHP-1NLRP3Caspase-1IL-1βBV.2LPSInhibitorinhibitorinhibit

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