2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis DNA/RNA Synthesis Caspase Bcl-2 Family MDM-2/p53
  4. Apoptosis inducer 56

Apoptosis inducer 56 是一种凋亡 (apoptosis) 诱导剂。Apoptosis inducer 56 通过与 DNA 小沟结合诱导 DNA 损伤 (γH2AX 和 p-ATM 表达上调)。Apoptosis inducer 56 通过 S 期细胞周期阻滞诱导内源性凋亡 (p53 和 Bax/Bcl-2 比值上调，以及 caspase-7 裂解)。Apoptosis inducer 56 对癌细胞的选择性高于正常乳腺上皮细胞。Apoptosis inducer 56 可用于乳腺癌的研究。

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Apoptosis inducer 56

Apoptosis inducer 56 Chemical Structure

CAS No. : 952306-31-9

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Apoptosis inducer 56 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 56 is an apoptosis inducer. Apoptosis inducer 56 induces DNA damage (upregulation of γH2AX and p-ATM expression) by minor groove binding. Apoptosis inducer 56 induces intrinsic apoptosis (upregulation of p53 and Bax/Bcl-2 ratio, cleaved caspase-7) via S-phase cell cycle arrest. Apoptosis inducer 56 shows selectivity for cancer cells over normal breast epithelial cells. Apoptosis inducer 56 can be used for the research of breast cancer[1].

IC50 & Target[1]

Caspase-7

 

Bax

 

Bcl-2

 

体外研究
(In Vitro)

Apoptosis inducer 56 (compound 1) (5-60 μM；作用 24 小时) 可选择性诱导人乳腺癌 MCF-7 细胞产生细胞毒性，其 IC50 为 21.18 μM，而在非恶性乳腺上皮 MCF-10A 细胞中未表现出显著细胞毒性[1]。
Apoptosis inducer 56 (21.18 μM；24 h) 可抑制人乳腺癌 MCF-7 细胞的增殖和集落形成，并诱导细胞发生 S 期细胞周期阻滞[1]。
Apoptosis inducer 56 (21.18 μM；24 h) 可诱导人乳腺癌 MCF-7 细胞发生 45% 的凋亡，且不会诱导非恶性乳腺癌上皮细胞 MCF-10A 发生凋亡[1]。
Apoptosis inducer 56 (21.18 μM；24 h) 可在 MCF-7 人乳腺癌细胞中诱导 DNA 损伤介导的细胞凋亡，并可诱导 75.8% 的细胞发生线粒体膜去极化[1]。
Apoptosis inducer 56 (21.18 μM) 可激活 MCF-7 人乳腺癌细胞中的 DNA 损伤应答 (上调 γ-H2AX、p-ATM、p-Chk2) 并抑制 DNA 修复 (下调 p-BRCA1)[1]。
Apoptosis inducer 56 (21.18 μM；24 h) 通过上调促凋亡蛋白、细胞色素 c 释放、半胱天冬酶激活及 PARP 切割，诱导人乳腺癌 MCF-7 细胞发生线粒体依赖性凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 56 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7 human breast cancer cells, MCF-10A non-malignant breast epithelial cells
Concentration: 5, 10, 20, 40, 60 μM
Incubation Time: 24 h
Result: Induced cytotoxicity in MCF-7 cells with an IC₅₀ of 21.18 ± 2.01 μM; maintained >70% viability in MCF-10A cells across 5, 10, 20, 40, 60 μM.

Cell Proliferation Assay[1]

Cell Line: MCF-7 human breast cancer cells
Concentration: 21.18 μM
Incubation Time: 24 h
Result: Reduced cell proliferation from 83.1% (control) to 66.3%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 human breast cancer cells
Concentration: 21.18 μM
Incubation Time: 24 h
Result: Increased S-phase cell accumulation from 17.4% (control) to 30.1%.

Apoptosis Analysis[1]

Cell Line: MCF-7 human breast cancer cells, MCF-10A non-malignant breast epithelial cells
Concentration: 21.18 μM
Incubation Time: 24 h
Result: Induced 45% apoptosis in MCF-7 cells compared to 2.62% in the control group; maintained 95.8% viability in MCF-10A cells after 24 h treatment.

Apoptosis Analysis[1]

Cell Line: MCF-7 human breast cancer cells
Concentration: 21.18 μM
Incubation Time: 24 h
Result: Caused a substantial increase in TUNEL-positive cells (green fluorescence) compared to the untreated group.

Western Blot Analysis[1]

Cell Line: MCF-7 human breast cancer cells
Concentration: 21.18 μM
Incubation Time: 24 h
Result: Upregulated pro-apoptotic Bim and Bax; downregulated anti-apoptotic Bcl2 and Bcl-xL; elevated p53; suppressed survivin; induced cytochrome c release from mitochondria to cytoplasm; upregulated Apaf-1; activated caspase-7 and caspase-9 via cleavage; induced PARP cleavage.
体内研究
(In Vivo)

Apoptosis inducer 56 (compound 1) (1-10 mg/kg；灌胃；每日给药；连续 28 天) 在 BALB/c 小鼠中给药剂量高达 10 mg/kg 时仍具有安全性，对血液学、生物化学、肾脏或肝脏相关指标无显著毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (adult female, 25-28 g)[1]
Dosage: 1, 2.5, 5, 10 mg/kg
Administration: p.o.; daily; 28 days
Result: Detected no significant adverse effects on liver, renal, biochemical, or hematological parameters; observed no treatment-related behavioral deviations; maintained stable body weights across all dose groups; showed no structural abnormalities in liver and kidney tissues via histopathological analysis.
分子量

271.34

Formula

C11H17N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 56 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Apoptosis inducer 56952306-31-9Apoptosis inducer56Apoptosis inducer-56ApoptosisDNA/RNA SynthesisCaspaseBcl-2 FamilyMDM-2/p53BaxATM kinaseDNA damageBcl-2caspase-7breast cancerp53MCF-7 human breast cancer cellsMCF-10A breast epithelial cellsBALB/c miceInhibitorinhibitorinhibit

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