2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism
  4. Apoptosis inducer 59

Apoptosis inducer 59，一种基于樟脑磺酰胺的噻唑腙衍生物，是一种具有抗肿瘤活性的细胞凋亡 (apoptosis) 诱导剂。Apoptosis inducer 59 可抑制细胞迁移与侵袭，引发 S 期阻滞，诱导活性氧 (ROS) 产生并使线粒体膜电位去极化。Apoptosis inducer 59 可用于癌症研究，例如乳腺癌。

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Apoptosis inducer 59

Apoptosis inducer 59 Chemical Structure

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Apoptosis inducer 59 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 59, a camphorsulfonamide-based thiazolylhydrazone derivative, is a apoptosis inducer with antitumor activity. Apoptosis inducer 59 can inhibit cell migration and invasiveness, cause S phase arrest, induce ROS production and depolarise mitochondrial membrane potential. Apoptosis inducer 59 can be used for the research of cancer, such as breast cancer[1].

体外研究
(In Vitro)

Apoptosis inducer 59 (Compound 5J) (48 h) 可强效且选择性地抑制 MCF-7 乳腺癌细胞增殖，其 IC50 为 12.80 ± 0.12 μM，而对正常 LO2 肝细胞的细胞毒性低 (IC50 >50 μM)[1]。
Apoptosis inducer 59 (5-25 μM; 24 h) 可剂量依赖性地诱导 MCF-7 乳腺癌细胞发生凋亡，其早期与晚期凋亡的总发生率为 25.52%[1]。
Apoptosis inducer 59 (5-25 μM; 24 h) 可诱导 MCF-7 乳腺癌细胞发生 S 期细胞周期阻滞，将 S 期细胞占比从 21.78% 提升至 31.32%[1]。
Apoptosis inducer 59 (5-25 μM; 24-48 h) 可抑制 MCF-7 乳腺癌细胞的迁移和侵袭能力[1]。
Apoptosis inducer 59 (5-25 μM) 以剂量依赖的方式增加 MCF-7 乳腺癌细胞内的活性氧 (ROS) 生成[1]。
Apoptosis inducer 59 (5-25 μM) 可浓度依赖性地去极化 MCF-7 乳腺癌细胞中的线粒体膜电位，进而引发线粒体功能障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 59 相关抗体:

Apoptosis Analysis[1]

Cell Line: MCF-7 breast cancer cells
Concentration: 5, 10 and 25 μM
Incubation Time: 24 h
Result: Increased apoptosis rates in MCF-7 cells
(10.62%, 11.60%, 18.17%).
Showed early and late apoptosis rate of 25.52% higher than the control group (9.50%).
分子量

531.09

Formula

C25H27ClN4O3S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 59 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 59Apoptosis inducer59Apoptosis inducer-59ApoptosisReactive Oxygen Species (ROS)Mitochondrial MetabolismMCF-7breast cancerS phasemitochondrial membrane potentialapoptosisreactive oxygen speciesInhibitorinhibitorinhibit

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