2. Apoptosis
  3. Survivin
  4. AQIM-I

AQIM-I 是一种存活蛋白抑制剂，通过抑制存活蛋白表达和集落形成。 AQIM-I 诱导 ROS 产生、细胞凋亡、细胞周期停滞、DNA 损伤和自噬。 AQIM-I 抑制非小细胞肺癌细胞 A549，IC50 值为 9 nM。

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AQIM-I

AQIM-I Chemical Structure

CAS No. : 2247881-73-6

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AQIM-I 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AQIM-I is an inhibitor of survivin via inhibits survivin expression and colony formation. AQIM-I induces ROS production, apoptosis, cell cycle arrest, DNA damage, and autophagy. AQIM-I inhibits nonsmall cell lung cancer cells A549 with an IC50 value of 9 nM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
143B IC50
0.59 μM
Compound: 60; AQIM-I
Antiproliferative activity against human 143B cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human 143B cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
5637 IC50
0.18 μM
Compound: 60; AQIM-I
Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
A549 IC50
0.009 μM
Compound: 60; AQIM-I
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs in presence of scramble siRNA by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs in presence of scramble siRNA by MTT assay
[PMID: 38079530]
A549 IC50
0.98 μM
Compound: 60; AQIM-I
Antiproliferative activity against survivin silenced human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against survivin silenced human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
ASPC1 IC50
0.25 μM
Compound: 60; AQIM-I
Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
BXPC-3 IC50
0.07 μM
Compound: 60; AQIM-I
Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
HUVEC IC50
6.66 μM
Compound: 60; AQIM-I
Antiproliferative activity against human HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
HeLa IC50
1.16 μM
Compound: 60; AQIM-I
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
HepG2 IC50
0.25 μM
Compound: 60; AQIM-I
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
MCF7 IC50
0.06 μM
Compound: 60; AQIM-I
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
MRC5 IC50
6.9 μM
Compound: 60; AQIM-I
Antiproliferative activity against human MRC5 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MRC5 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
NCI-H1299 IC50
0.51 μM
Compound: 60; AQIM-I
Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
NCI-H460 IC50
0.14 μM
Compound: 60; AQIM-I
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
NIH3T3 IC50
14 μM
Compound: 60; AQIM-I
Antiproliferative activity against mouse NIH3T3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against mouse NIH3T3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
PANC-1 IC50
0.08 μM
Compound: 60; AQIM-I
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
TE-1 IC50
0.05 μM
Compound: 60; AQIM-I
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38079530]
分子量

404.20

Formula

C17H13IN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AQIM-I 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AQIM-I2247881-73-6SurvivinSurvivin InhibitorInhibitorinhibitorinhibit

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