2. Immunology/Inflammation
  3. COX
  4. AS1-6

AS1-6 是一种选择性 COX-2 抑制剂，IC50 为 2.7 μM。AS1-6 对 COX-1 的 IC50 为 12.6 μM。AS1-6 可发挥显著的抗炎和镇痛活性。AS1-6 可用于非甾体抗炎剂方面的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AS1-6

AS1-6 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AS1-6 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AS1-6 is a selective COX-2 inhibitor with an IC50 of 2.7 μM. AS1-6 has an IC50 of 12.6 μM for COX-1. AS1-6 exerts significant anti-inflammatory and analgesic activities. AS1-6 can be used in research on non-steroidal anti-inflammatory agents[1].

IC50 & Target[1]

COX-2

2.7 μM (IC50)

体外研究
(In Vitro)

AS1-6 (10-200 μg/mL；24 h) 对卤虫的毒性较低，其 LD50 > 200 μg/mL[1]。
AS1-6 (30 μg/mL; 24-48 h) 对 3T3 成纤维细胞无活性，表明其对非癌细胞的毒性较低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AS1-6 相关抗体:
体内研究
(In Vivo)

AS1-6（10 mg/kg；腹腔注射；单次剂）在成年白化小鼠中，通过角叉菜胶诱导足肿胀模型显示出显著抗炎活性、福尔马林诱导足舔模型显示出镇痛活性、醋酸诱导扭体模型显示出显著镇痛活性，且能下调 COX-2 相关炎症介质表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino mice (adult male and female, 6-7 weeks old, 25-30 g)[1]
Dosage: 10 mg/kg
Administration: i.p.; single dose
Result: Significantly reduced paw thickness to 4.00 mm and COX-2 protein levels in the carrageenan-induced paw edema model.
Remarkably suppressed nociceptive behaviors in both the early phase and late phase, indicating both peripheral and central antinociceptive activity in formalin-induced paw licking test.
Significantly decreased the number of writhing responses in the acetic acid-induced writhing test.
分子量

409.84

Formula

C23H17ClFNO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AS1-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS1-6COXCyclooxygenaseCOX-1miceCOX-23T3 fibroblasthuman erythrocytescarrageenanpaw edema modelred blood cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AS1-6
目录号：
HY-181123
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z