2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Adrenergic Receptor 5-HT Receptor Histamine Receptor
  4. Atiprosine

Atiprosine (AY-28228) 是一种口服有效的选择性 α1-肾上腺素能受体 (α1-adrenergic receptor) 拮抗剂，其 pA2 为 8.11。Atiprosine 对 α2-肾上腺素受体 (α2-adrenergic receptor)、5-HT₂ 受体 (5-HT₂ receptor)、H₁ 受体 (H₁ receptor) 均有拮抗活性，其 pA2 分别为 6.04、6.87、7.32。Atiprosine 在大鼠、狗和猴子中具有抗高血压和降血压作用。Atiprosine 可用于研究心血管和精神疾病。

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Atiprosine

Atiprosine Chemical Structure

CAS No. : 89303-63-9

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Atiprosine 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor). The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.

IC50 & Target>[2]

α1-adrenergic receptor

8.11 (pA2)

α2-adrenergic receptor

6.04 (pA2)

5-HT2 Receptor

6.87 (pA2)

H1 Receptor

7.32 (pA2)

分子量

311.46

Formula

C20H29N3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Atiprosine 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atiprosine89303-63-9AY-28228AY28228AY 28228Adrenergic Receptor5-HT ReceptorHistamine ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptoralpha-1 adrenoceptor antagonistpA2 valuereceptor selectivityketanserinindoramin5-HT2 receptorhistamine H1 receptorvascular smooth muscleInhibitorinhibitorinhibit

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HY-119854
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