2. GPCR/G Protein JAK/STAT Signaling Stem Cell/Wnt Epigenetics Protein Tyrosine Kinase/RTK Apoptosis
  3. Protease Activated Receptor (PAR) JAK Apoptosis
  4. Atopaxar hydrobromide

Atopaxar hydrobromide  (Synonyms: E5555 hydrobromide; ER 172594-06)

目录号: HY-18200B
产品使用指南 技术支持

Atopaxar (E5555) hydrobromide 是一种高效、有口服活性的，选择性的，可逆凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。Atopaxar hydrobromide 是一种抗血小板剂，能干扰血小板信号。Atopaxar hydrobromide 可用于动脉粥样硬化血栓性疾病的研究。

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Atopaxar hydrobromide

Atopaxar hydrobromide Chemical Structure

CAS No. : 474550-69-1

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Atopaxar hydrobromide 的其他形式现货产品:

Customer Review

Other Forms of Atopaxar hydrobromide:

Atopaxar hydrobromide 相关抗体

Top Publications Citing Use of Products

查看 Protease Activated Receptor (PAR) 亚型特异性产品:

查看所有亚型
PAR1 PAR2 PAR4

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atopaxar (E5555) hydrobromide is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar hydrobromide, an antiplatelet agent, interferes with platelet signaling. Atopaxar hydrobromide can be used for the research of atherothrombotic disease[1][2].

IC50 & Target

PAR1

5.1 nM (IC50)

体外研究
(In Vitro)

Atopaxar hydrobromide (0.0001-10 μM; 1h) inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC50 of 0.019 μM[2].
Atopaxar hydrobromide shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50s of 0.064 and 0.031 μM, respectively, but has no effect on platelet aggregation induced by either ADP or collagen[2].
Atopaxar hydrobromide shows potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP with IC50s of 0.13 and 0.097 μM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Atopaxar hydrobromide 相关抗体:
体内研究
(In Vivo)

Atopaxar (30-100 mg/kg; p.o.) hydrobromide causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model[2].
Atopaxar hydrobromide does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pigs, PIT model[2]
Dosage: Oral administration
Administration: 10 mg/kg, 30 mg/kg, 100 mg/kg
Result: Prolonged the time to occlusion by 1.8-fold and 2.4-fold at 30 mg/kg and 100 mg/kg, respectively, compared with controls.
Clinical Trial
分子量

608.54

Formula

C29H39BrFN3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    Atopaxar hydrobromide (E5555) is prepared in the 0.5% methylcellulose solution[2].

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Atopaxar hydrobromide 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atopaxar474550-69-1E5555 ER 172594-06E 5555E-5555Protease Activated Receptor (PAR)JAKApoptosisThrombin receptorsJanus kinasethrombinreceptorprotease-activatedreceptor-1PAR-1atherothromboticplateletssignalingInhibitorinhibitorinhibit

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var dragLogin = document.querySelector("#loginProLogin"); dragMoves(dragGeneral); dragMoves(dragLogin); }); // var initStopn = 0; // var targetTop = 537; // var targetTopDiv = 0; // var loginDivheight = 430; // isCnProdetail = true; // $('html,body').animate({scrollTop:0},1000); //$(".zhuce").offset().top; // function prodetailLogin() { // var stopn = $(window).scrollTop(); // var stopn2 = $(window).scrollTop() - initStopn; // var promise = $("#main_nav").offset().top; // var winheight= ($(window).height()); // var promisepro = 716; // // // // if (stopn >= promise) { // $('.pro_mask').css("top","88px"); // } // else { // $('.pro_mask').css("top","120px"); // } // // if (winheight < promisepro) { // if (stopn2 > 0) { // if (targetTop > 368) { // targetTop = targetTop - stopn2 <= 368 ? 368 : targetTop - stopn2; // } // } // } else { // if (stopn2 < 0) { // targetTop = targetTop - stopn2 >= 537 ? 537 : targetTop - stopn2; // } // loginDivheight = 430; // $('.pro_login').removeClass('divlogoverflow'); // } // // if (targetTop <= 368) { // let h1 = 650 - winheight; // let new_loginDivheight = h1 >= 0 ? 430 - h1 : 430 ; // $('.pro_login').height(new_loginDivheight); // let c_h = loginDivheight - new_loginDivheight; // targetTop = targetTop - c_h / 2; // loginDivheight = new_loginDivheight; // if (new_loginDivheight < 430) { // $('.pro_login').addClass('divlogoverflow'); // } else { // $('.pro_login').removeClass('divlogoverflow'); // } // // } // // $('.pro_login').css("top", targetTop + "px"); // initStopn = $(window).scrollTop(); // } var sel_array = $('[name="pro_cart_mg_num"]'); var mg_array = $('[name="pro_cart_mg"]'); var dw_sel_array = $('[name="pro_cart_dw_num"]'); var dw_array = $('[name="pro_cart_dw"]'); var eta_showStockType = "0"; var eta_infringementType = "1"; function updateProETA(){ var isChange = false; var isPrepare = false; var isETA = false; // var sel_num = $(currentE).val(); // if (parseInt(sh_stock_num) < parseInt(sel_num)) { // $('#pro_detail_eta').show(); // $('#pro_detail_eta').html(getEtaCnMessage()); // } else { // $('#pro_detail_eta').hide(); // $('#pro_detail_eta').html(""); // } var delivery = ''; dw_sel_array.each(function(index,domEle) { var option_dw = $(dw_array.eq(index)).val().split(";"); var dw_sh_stock_num = option_dw[6]; var dw_us_stock_num = option_dw[7]; var dw_select_num = $(domEle).val(); if (parseInt(dw_sh_stock_num) < parseInt(dw_select_num)) { isETA = true; if (dw_us_stock_num == 9527) { isChange = true; } if (dw_us_stock_num == 99999) { isPrepare = true; } delivery = $(domEle).closest('tr').find('.pro_price_3').text() return false; } }); //alert('isDW:'+isDW); sel_array.each(function(index,domEle){ var select_num = $(domEle).val(); var option_mg = $(mg_array.eq(index)).val().split(";"); var sh_stock_num = option_mg[6]; var us_stock_num = option_mg[7]; var eta_message = ''; if (parseInt(sh_stock_num) < parseInt(select_num)) { isETA = true; if (us_stock_num == 9527) { isChange = true; } if (us_stock_num == 99999) { isPrepare = true; } delivery = $(domEle).closest('tr').find('.pro_price_3').text() return false; } }); // 20200519 wdf if (isETA == true) { if (isPrepare || isChange) { $('#pro_detail_eta').html("预计 " + delivery + " 发货"); } else { var catNo = "HY-18200B"; changeCnEtaMessage(isChange); //$('#pro_detail_eta').show(); $('#pro_detail_eta').html(getEtaCnMessage(catNo, isChange)); } } else { //$('#pro_detail_eta').hide(); $('#pro_detail_eta').html(""); } } function qtyChange(){ updateProETA(); } // Product Isoform by WDF 20180508 $(function () { fnSetIC50Style(); fnIsoformWidth(); proRelatedImgCN(); //normalSalineDisplacement(); }); // Isoform width function fnIsoformWidth(){ var isoformProList = $(".isoform-pro-list"); var isoformProListLen = isoformProList.length; for(var i = 0; i < isoformProListLen; i++){ var isoformProSpan = isoformProList.eq(i).find("span"); var isoformProSpanLen = isoformProSpan.length; if(isoformProSpanLen>4) { isoformProSpan.parent().css({"width":"100%"}); isoformProSpan.css({"width":"auto"}); } else { isoformProSpan.parent().css({"width":(isoformProSpanLen/4*100)+"%" }); isoformProSpan.css({"width":(1/isoformProSpanLen*100)+"%" }); } } } /* * Target&IC50 Table => 原理 * 1. 计算每个格子的宽度，如果格子的总宽度 <= iContainerW(固定行宽)，则一行显示; 否则多行显示 * 2. 多行的情况: 列数 = iContainerW/最宽单元格的列宽(取整); 列宽 = iContainerW/列数 * 3. 如果一行中, IC50值全是空，那么这一行 IC50 全隐藏，Isoform 垂直居中对齐 */ function fnSetIC50Style(){ var oContainer = $("#pro-ic50-tbl"); var iContainerW = 827; var spanLen = oContainer.find("span").length; var tdLen = spanLen/2; // 单元格总数 var spanArr = []; var spanTotalW = 0; var spanwMax = 0; // span 相加总长度 var lastW = 0; if(tdLen > 1){ for(var i = 0; i < tdLen; i++){ var spanW = [oContainer.find("td").eq(i).find("span").eq(0).outerWidth(),oContainer.find("td").eq(i).find("span").eq(1).outerWidth()].max(); spanArr.push(spanW); spanTotalW += spanW; if(i==tdLen-1){ lastW = oContainer.find("td").eq(i).find("span").eq(0).outerWidth(); } } } spanwMax = spanArr.max(); // console.log("spanwMax= " + spanwMax); // console.log("spanArr=" +spanArr); // 如果 spanwMax > iContainerW 分行; 否则, 一行显示 if(spanTotalW <= iContainerW){ oContainer.find("td").addClass("ic50-td0"); oContainer.find("td:last-child").css({"width": (iContainerW-lastW)+"px"}); // 最后一列宽度 oContainer.find(".ic50-td0").wrapAll(""); }else { var trtdNum = parseInt(iContainerW / spanwMax); // 每一行的列数 var tdWidth = iContainerW/trtdNum; //列宽 var trLen = spanLen/2/trtdNum; // 总行数 var lastTrNum = spanLen/2%trtdNum; //最后一行的个数 var lastColspan = trtdNum+1-lastTrNum; // 最后一行需要合并的单元格数 for (var j = 0; j < tdLen; j++) { for (var k = 0; k < trLen; k++) { if (parseInt(j / trtdNum) == k) { oContainer.find("td").eq(j).addClass("ic50-td" + k); } } } oContainer.find("td").css({"width": tdWidth + "px"}); // 设置列宽 oContainer.find("td:last-child").attr({"colspan": lastColspan}); //最后一行合并的单元格数量 oContainer.find("td:last-child").css({"width": lastColspan*tdWidth+"px"}); // 最后一列宽度 // tr 分组 for (var k = 0; k < trLen; k++) { oContainer.find(".ic50-td" + k).wrapAll(""); } } oContainer.find("td.ic50-td0 > p:first-child").css({"border-top":"0"}); // 第一行 p 的上border 是0 // 如果一行中 IC50 全是空，则这一行隐藏 var iTrLength = oContainer.find("tr>tr").length; var str = []; var tdLength = 0; console.log("tr="+iTrLength); for(var a = 0; a < iTrLength; a++){ tdLength = oContainer.find("tr>tr").eq(a).find("td").length; for(var b = 0; b < tdLength; b++ ){ var aa = oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(1).text().replace(/\,|(^\s*)|(\s*$)/g, ""); str[a] += aa; } console.log("str[a]="+str[a]); if(str[a] == "undefined" || str[a] == "" || str[a] == null){ for(var b = 0; b < tdLength; b++ ){ oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(1).css({"display":"none"}); oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(0).css({"padding":"0"}); oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(0).find("span").css({"padding":"8px 18px 6px"}); } } } } //最小值 Array.prototype.min = function() { var min = this[0]; var len = this.length; for (var i = 1; i < len; i++){ if (this[i] < min){ min = this[i]; } } return min; } //最大值 Array.prototype.max = function() { var max = this[0]; var len = this.length; for (var i = 1; 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pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="RP-HPLC"){ if (isShowPT) { coa_txt = coa_txt + "RP-HPLC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "RP-HPLC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-RP-HPLC-link', arrPdf[i].objName, 'RP-HPLC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="NP-HPLC"){ if (isShowPT) { coa_txt = coa_txt + "NP-HPLC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "NP-HPLC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-NP-HPLC-link', arrPdf[i].objName, 'NP-HPLC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="MS"){ if (isShowPT) { coa_txt = coa_txt + "MS ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "MS ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-MS-link', arrPdf[i].objName, 'MS', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="LCMS"){ if (isShowPT) { coa_txt = coa_txt + "LCMS ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "LCMS ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-LCMS-link', arrPdf[i].objName, 'LCMS', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="IR"){ if (isShowPT) { coa_txt = coa_txt + "IR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "IR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-IR-link', arrPdf[i].objName, 'IR', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="GC"){ if (isShowPT) { coa_txt = coa_txt + "GC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "GC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-GC-link', arrPdf[i].objName, 'GC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="OR"){ if (isShowPT) { coa_txt = coa_txt + "OR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "OR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-OR-link', arrPdf[i].objName, 'OR', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="SDS-PAGE"){ if (isShowPT) { coa_txt = coa_txt + "SDS-PAGE ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "SDS-PAGE ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-SDS-PAGE-link', arrPdf[i].objName, 'SDS-PAGE', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="Other Report"){ if (isShowPT) { coa_txt = coa_txt + "Other Report ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "Other Report ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-Other-Report-link', arrPdf[i].objName, 'Other Report', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="SEC-HPLC"){ if (isShowPT) { coa_txt = coa_txt + "SEC-HPLC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "SEC-HPLC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-SEC-HPLC-link', arrPdf[i].objName, 'SEC-HPLC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } } }else{ if(arrPdf[i].objFile=="Purity"){ batch_txt += "纯度： " + arrPdf[i].objName ; } else if (arrPdf[i].objFile=="Assay") { batch_txt += "含量： " + arrPdf[i].objName; } else{ batch_txt += "ee.: " + arrPdf[i].objName ; } } } //pdf_batch.innerHTML = batch_txt; //pdf_coa.innerHTML = coa_txt; $("#productDetailBatch_pdf_batch").html(batch_txt); $("#productDetailBatch_pdf_coa").html(coa_txt); } } if (pdf_array.length>0) { $.each(pdf_array, function(index, pdfobjTemp){ //console.log(pdfobjTemp.pdfname); $("#" + pdfobjTemp.pdfid).click(function () { pagePdfObj = pdfobjTemp; pagePdfObj.proName = `Atopaxar hydrobromide`; $("#J-HNMR-form .title").html("Request for " + pagePdfObj.pdftype + " Report"); $("#J-HNMR-form #lotNo").val(pagePdfObj.lotNo); modalOpen("#J-HNMR-form"); getUserBaseMessage(); }); }); } } }); } function Gettext(obj){ var txt=obj.options[obj.options.selectedIndex].text; return txt; } cart_sart(); //]]> function findClinicalsByCatalogNo(){ var catalogNo = "HY-18200B"; $.ajax({ url:'mce_productDetail!findClinicalsByCatalogNo.shtml?mathdom='+Math.random(), type: 'post', cache:false, data:{'pro_catalogNo':catalogNo}, dataType: 'json', success:function(data){ var str_head = "" + "" + "NCT Number" + "Sponsor" + "Condition" + "Start Date" + "Phase" + "" + "" + ""; var str_foot = ""; var str_content = ""; $.each(data, function(i, item) { if (i==3) { //alert(i+","+item.phase); str_content += " "; } str_content += "" + item.nctNumber + ""; str_content += "" + item.sponsorCollaberators + ""; str_content += "
" + item.activeCondition + "
"; str_content += "" + item.startDate + ""; str_content += "" + item.phase + ""; }); $('#clinical_seo').html(str_head + str_content + str_foot); proClinicalStyle(); } }) } $("#datasheet_url").show(); $("#datasheet_footer_url").show(); $("#datasheet_span").show(); function checkUrl(c_url,type_id) { /*$.ajax({ url:'mce_productDetail!chenkUrlStatus.shtml?mathdom='+Math.random(), type: 'post', cache:false, data:{'curl':c_url}, dataType: 'json', success:function(data){ if (data.checkUrl == "success") { $("#" + type_id + "_url").show(); $("#" + type_id + "_footer_url").show(); $("#" + type_id + "_span").show(); } } })*/ $.ajax({ url: c_url, type: 'get', cache: false, dataType: 'jsonp', processData: false, complete: function(response) { if (response.status == 200) { $("#" + type_id + "_url").show(); $("#" + type_id + "_footer_url").show(); $("#" + type_id + "_span").show(); } }, error: function(data) {} }); } $(function(){ findClinicalsByCatalogNo(); fnCPDRelated('#J-cpd-related-lib'); //fnCPDRelated('#J-cpd-related-mol'); //findRelatedProArray(); var pmsOutSessionId = $.cookie('pms-out-init'); console.log(pmsOutSessionId) //遮罩层屏蔽 if (pmsOutSessionId != "" && pmsOutSessionId !=null && pmsOutSessionId != undefined){ $("#loginProLogin").hide(); $("#loginProGeneral").hide(); $("#main").removeClass("gray-text");//遮罩层 $("#detail_price_pro").removeClass("is-disabled");//按钮控制 // // $("#loginProGeneral").hide(); // $("#loginProMask").removeClass("pro_mask"); } }); (function($, h, c) { var a = $([]), e = $.resize = $.extend($.resize, {}), i, k = "setTimeout", j = "resize", d = j + "-special-event", b = "delay", f = "throttleWindow"; e[b] = 350; e[f] = true; $.event.special[j] = { setup : function() { if (!e[f] && this[k]) { return false } var l = $(this); a = a.add(l); $.data(this, d, { w : l.width(), h : l.height() }); if (a.length === 1) { g() } }, teardown : function() { if (!e[f] && this[k]) { return false } var l = $(this); a = a.not(l); l.removeData(d); if (!a.length) { clearTimeout(i) } }, add : function(l) { if (!e[f] && this[k]) { return false } var n; function m(s, o, p) { var q = $(this), r = $.data(this, d); r.w = o !== c ? o : q.width(); r.h = p !== c ? p : q.height(); n.apply(this, arguments) } if ($.isFunction(l)) { n = l; return m } else { n = l.handler; l.handler = m } } }; function g() { i = h[k](function() { a.each(function() { var n = $(this), m = n.width(), l = n.height(), o = $ .data(this, d); if (m !== o.w || l !== o.h) { n.trigger(j, [ o.w = m, o.h = l ]) } }); g() }, e[b]) } })(jQuery, this); $('#loginProLogin').on('mousedown', function() { $('#loginProLogin').css('cursor','grab') }); $('#loginProLogin').on('mouseup', function() { $('#loginProLogin').css('cursor','move') }); $('#loginProGeneral').on('mousedown', function() { $('#loginProGeneral').css('cursor','grab') }); $('#loginProGeneral').on('mouseup', function() { $('#loginProGeneral').css('cursor','move') });