2. Stem Cell/Wnt GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease Anti-infection Immunology/Inflammation PI3K/Akt/mTOR JAK/STAT Signaling
  3. Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
  4. Atranorin

Atranorin  (Synonyms: 荔枝素)

目录号: HY-N2907 纯度: 99.68%
COA 产品使用指南 技术支持

Atranorin 是地衣的次生代谢产物和 Akt 抑制剂。Atranorin 具有抗菌、抗炎抗氧化、抗糖化、 镇痛和抗肿瘤等多种活性。Atranorin 对 DPPH、ABTS 自由基清除的 IC50 分别为 117 μM 和小于 10 μM。Atranorin 也具有促进伤口愈合等作用。Atranorin 能够用于骨髓增生异常综合征、肿瘤和炎症等多种疾病的研究。

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Atranorin

Atranorin Chemical Structure

CAS No. : 479-20-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2310
In-stock
1 mg ￥850
In-stock
5 mg ￥2100
In-stock
10 mg ￥3500
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Atranorin:

Atranorin 相关抗体

Top Publications Citing Use of Products

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Wnt1 Wnt3 Wnt5 Wnt7

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC50 values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions[1][2][3][4][5].

体外研究
(In Vitro)

Atranorin (0.01-10 μg/mL; 3 h) 可保护 SH-SY5Y 细胞免受 H2O2 的细胞毒性[1]。
Atranorin (24 h) 在 THP-1、KG-1 和 Mono-Mac-1 细胞中可抑制 PD-L1 和 TIM-3 表达。机制与 AKT 通路抑制相关[2]。
Atranorin (0-10 μg/mL; 24-72 h) 可抑制 A549 细胞的迁移、侵袭。机制涉及对 AP-1、Wnt、STAT 通路及 RhoGTPase 活性的抑制[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Atranorin 相关抗体:
体内研究
(In Vivo)

Atranorin (10 mg/kg; 腹腔注射; 每 3 天 1 次; 2 周) 在小鼠肺癌模型中具有抗肿瘤的活性[3]。
Atranorin (1-5%; 软膏局部涂抹; 每日 1 次; 3-21 天) 在大鼠切除伤口模型中可促进伤口愈合[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice aged 8 weeks old treated LLC cells[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once every 3 days; 2 weeks
Result: Significantly reduced tumor volume, tumor weight, and nuclear Ki-67 immunoreactivity.
Downregulated target genes (e.g., KITENIN, STAT, c-myc) in tumor tissues.
Animal Model: Male Wistar rats (220-260 g) with full-thickness excisional wounds created by an 8 mm biopsy punch on the back[4]
Dosage: 1% and 5% in ointment form
Administration: Topical application as an ointment; once daily; 3, 7, 14 and 21 days
Result: Reduced wound areas significantly on days 3, 7, and 14 (particularly with 5% atranorin).
Induced earlier granulation tissue formation with increased fibroblastic and vascular components.
Improved collagen deposition and organization (with more type I collagen and dense interlaced arrangement in the 5% group).
Modulated myofibroblasts differentiation (reduced early myofibroblasts in the 5% group and promoted timely apoptosis by day 21).
分子量

374.34

Formula

C19H18O8
CAS 号
性状

固体

颜色

White to off-white

中文名称

荔枝素
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 12.5 mg/mL (33.39 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6714 mL 13.3568 mL 26.7137 mL
5 mM 0.5343 mL 2.6714 mL 5.3427 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Atranorin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6714 mL 13.3568 mL 26.7137 mL 66.7842 mL
5 mM 0.5343 mL 2.6714 mL 5.3427 mL 13.3568 mL
10 mM 0.2671 mL 1.3357 mL 2.6714 mL 6.6784 mL
15 mM 0.1781 mL 0.8905 mL 1.7809 mL 4.4523 mL
20 mM 0.1336 mL 0.6678 mL 1.3357 mL 3.3392 mL
25 mM 0.1069 mL 0.5343 mL 1.0685 mL 2.6714 mL
30 mM 0.0890 mL 0.4452 mL 0.8905 mL 2.2261 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atranorin479-20-9荔枝素WntRasEndogenous MetaboliteBacterialFungalPD-1/PD-L1Tim3AktAP-1STATPD-1/Programmed death-ligand 1T-Cell Immunoglobulin and Mucin Containing Protein-3CD366PKBProtein kinase BActivator Protein 1lung cancer modelexcisional wound modelSH-SY5YTHP-1KG-1Mono-Mac-1A549Inhibitorinhibitorinhibit

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