2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. AU-461

AU-461 是一种口服有效的、可逆的胃 H⁺/K⁺ ATP 酶 (H⁺/K⁺ ATPase) 抑制剂，其对兔源酶和猪源酶的 IC₅₀ 分别为 12.15 和 4.20 μM。AU-461 与激活的阳离子 K⁺ 竞争 (Kᵢ = 1.64 μM)。AU-461 既减少了组胺刺激的胃酸分泌，也减少了大鼠的基础胃酸分泌。AU-461 抑制乙醇或者氢氧化钠所导致的溃疡形成，且使血浆胃泌素水平恢复正常水平。AU-461 可用于研究消化性溃疡。

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AU-461

AU-461 Chemical Structure

CAS No. : 220854-06-8

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AU-461 相关抗体

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  • 生物活性

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生物活性

AU-461 is an orally active and reversible inhibitor of the gastric H⁺/K⁺ ATPase with IC₅₀ values for rabbit-derived and pig-derived enzymes are 12.15 μM and 4.20 μM respectively. AU-461 competes with activated cationic K⁺ (Kᵢ = 1.64 μM). AU-461 reduces both histamine-stimulated gastric acid secretion and basal gastric acid secretion in rats. AU-461 inhibits ulcer formation caused by ethanol or sodium hydroxide, and restores the plasma gastrin level to normal. AU-461 can be used for the study of peptic ulcers[1].

分子量

447.45

Formula

C23H24F3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AU-461 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AU-461220854-06-8AU461AU 461Na+/K+ ATPaseSodium potassium pumpH+/K+ ATPase inhibitorreversible inhibitionantiulcer agentgastric acid secretionplasma gastrincompetitive inhibitionInhibitorinhibitorinhibit

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HY-165498
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