2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. JAK STAT Apoptosis
  4. AUH-6-96

AUH-6-96 是一种 JAK/STAT 信号抑制剂。AUH-6-96 可降低果蝇细胞中由 Unpaired 诱导的转录活性，并阻断 STAT92E 的酪氨酸磷酸化。AUH-6-96 可阻断组成型及 IL-6 诱导的 STAT3 磷酸化。AUH-6-96 可降低酪氨酸磷酸化的 JAK3 水平。AUH-6-96 可通过下调 STAT3 下游抗凋亡基因的表达诱导癌细胞凋亡 (Apoptosis)。AUH-6-96 可选择性降低存在 JAK/STAT 信号通路异常的癌细胞的细胞活力。AUH-6-96 可用于霍奇金淋巴瘤、乳腺癌、前列腺癌的相关研究。

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AUH-6-96

AUH-6-96 Chemical Structure

CAS No. : 1005144-85-3

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AUH-6-96 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AUH-6-96 is a JAK/STAT signaling inhibitor. AUH-6-96 reduces Unpaired-induced transcriptional activity in Drosophila cells and blocks tyrosine phosphorylation of STAT92E. AUH-6-96 blocks both constitutive and IL-6-induced phosphorylation of STAT3. AUH-6-96 decreases the level of tyrosine-phosphorylated JAK3. AUH-6-96 induces cancer cell Apoptosis by downregulating the expression of anti-apoptotic genes downstream of STAT3. AUH-6-96 selectively reduces the viability of cancer cells with abnormal JAK/STAT signaling pathway. AUH-6-96 is applicable to related research on Hodgkin's lymphoma, breast cancer, and prostate cancer[1].

IC50 & Target[1]

JAK3

 

STAT3

 

体外研究
(In Vitro)

AUH-6-96 (5-40 μM; 24 h) 可抑制培养的黑腹果蝇 S2-NP 细胞中 STAT92E 的转录活性，其中 10 μM 处理可使活性降低 50% 以上，40 μM 处理 24 h 则可完全阻断该活性[1]。
AUH-6-96 (40 μM; 24 h) 几乎可以完全抑制瞬时转染的黑腹果蝇 S2-NP 细胞中 Upd 诱导的 STAT92E 酪氨酸磷酸化[1]。
AUH-6-96 (5-40 μM; 24 h) 以剂量依赖的方式抑制 MDA-MB-468 和 DU145 癌细胞中组成型 STAT3 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AUH-6-96 相关抗体:

Western Blot Analysis[1]

Cell Line: Human cancer cell lines (Hodgkin lymphoma L540, breast cancer MDA-MB-468, prostate cancer DU145)
Concentration: 5, 10, 20, 30, 40 μM
Incubation Time: 24 h
Result: Reduced constitutive phospho-STAT3 levels by more than 50% in L540 cells at 10 μM.
Almost completely inhibited phospho-STAT3 levels in L540 cells at 40 μM.
Caused a dramatic reduction in constitutive phospho-STAT3 levels in MDA-MB-468 and DU145 cells at 40 μM.
Left total STAT3 levels unchanged in all cell lines.

Western Blot Analysis[1]

Cell Line: Hodgkin lymphoma L540 cells
Concentration: 5, 10, 20, 30, 40 μM
Incubation Time: 24 h
Result: Almost completely eliminated constitutive phospho-JAK3 levels, while total JAK3 levels remained unchanged.
Inhibited phospho-STAT5 levels in a dose-dependent manner, with total STAT5 levels unchanged.
Did not affect Lyn phosphorylation at 20 μM.
Reduced phospho-Lyn levels but also lowered total Lyn levels at 40 μM.
Caused no changes in phospho-ERK1/2 or total ERK1/2 levels at concentrations up to 40 μM.
分子量

606.47

Formula

C28H20F6N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AUH-6-96 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AUH-6-961005144-85-3JAKSTATApoptosisJanus kinaseDrosophila cellsmultiple myelomaapoptosisJAK3breast cancerprostate cancerSTAT92ESTAT3human cancer cellshodgkin lymphomaInhibitorinhibitorinhibit

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