2. Cell Cycle/DNA Damage
  3. CDK
  4. BAY-958

BAY-958 是一种强效的 PTEFb/CDK9 抑制剂，表现出高选择性，尤其在 CDK 家族中。BAY-958 对 HeLa 和 MOLM-13 等癌细胞系显示出强大的抗增殖活性。BAY-958 具有良好的代谢稳定性。BAY-958 在小鼠异种移植模型中能有效抑制肿瘤生长，且无明显毒性。

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BAY-958

BAY-958 Chemical Structure

CAS No. : 1335490-39-5

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Other Forms of BAY-958:

BAY-958 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BAY-958 is a potent PTEFb/CDK9 inhibitor with high selectivity demonstrated, particularly within the CDK family. BAY-958 shows strong antiproliferative activity against cancer cell lines such as HeLa and MOLM-13. BAY-958 exhibits good metabolic stability. BAY-958 effectively inhibits tumor growth in mouse xenograft models without significant toxicity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
1 μM
Compound: 40
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method
[PMID: 32866383]
HeLa IC50
1000 nM
Compound: 49; BAY-958
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay
[PMID: 32870008]
MOLM-13 IC50
280 nM
Compound: 40
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method
[PMID: 32866383]
MOLM-13 IC50
280 nM
Compound: 49; BAY-958
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay
Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay
[PMID: 32870008]
分子量

389.40

Formula

C17H16FN5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BAY-958 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-9581335490-39-5BAY958BAY 958CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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产品名称：
BAY-958
目录号：
HY-121081
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