2. Neuronal Signaling MAPK/ERK Pathway
  3. Cholinesterase (ChE) p38 MAPK
  4. BChE/p38-α MAPK-IN-2

BChE/p38-α MAPK-IN-2 是一种 BChE 和 p38-α MAPK 双重抑制剂。BChE/p38-α MAPK-IN-2 对 hBChE 的 IC50 值为 5.1 nM，对 hAChE 的选择性达 1000 倍。BChE/p38-α MAPK-IN-2 对 p38α MAPK 的 IC50 值为 8.12 μM。BChE/p38-α MAPK-IN-2 具有神经保护作用，可用于神经系统疾病的研究，如阿尔茨海默病。

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BChE/p38-α MAPK-IN-2

BChE/p38-α MAPK-IN-2 Chemical Structure

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BChE/p38-α MAPK-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE/p38-α MAPK-IN-2 is a BChE and p38-α MAPK dual inhibitor. BChE/p38-α MAPK-IN-2 inhibits hBChE with an IC50 of 5.1 nM, showing 1000-fold selectivity over hAChE. BChE/p38-α MAPK-IN-2 inhibits p38α MAPK with an IC50 of 8.12 μM. BChE/p38-α MAPK-IN-2 exhibits neuroprotective effect and can be used for the research of neurological disease, such as Alzheimer’s disease[1].

IC50 & Target[1]

hBCHE

5.1 nM (IC50)

hAChE

3.1 μM (IC50)

体外研究
(In Vitro)

BChE/p38-α MAPK-IN-2 (10-50 μM) 在 BV2 小胶质细胞中无明显细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BChE/p38-α MAPK-IN-2 相关抗体:
体内研究
(In Vivo)

BChE/p38-α MAPK-IN-2 (5-10 mg/kg，腹腔注射，在测试前 60 分钟给药) 在 Albino Swiss (CD-1) 小鼠 Scopolamine (HY-N0296) 诱导的遗忘模型中，显著改善认知障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino Swiss (CD-1) mice with Scopolamine-induced amnesia[1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneally injection, 60 mins before tests
Result: Prolonged step-through latency in the passive avoidance task.
Enhanced the preference for novel objects in the novel object recognition task.
分子量

491.58

Formula

C27H33N5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BChE/p38-α MAPK-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE/p38-α MAPK-IN-2Cholinesterase (ChE)p38 MAPKBChEp38-α MAPKhBChEhAChEneuroprotectiveBV2Albino Swiss (CD-1)ScopolamineAlzheimer’s diseaseInhibitorinhibitorinhibit

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目录号：
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