2. PROTAC Immunology/Inflammation
  3. PROTACs BCL6
  4. BCL6-760

BCL6-760 是一种口服有效的 BCL-6 PROTAC 降解剂，其 EC50 为 0.8 nM。BCL6-760 仅降解 BCL6，对其他 CRBN 底物无影响。BCL6-760 在 OCI-LY-1 肿瘤的原位异种移植小鼠模型中显示出显著疗效。BCL6-760 可用于弥漫性大 B 细胞淋巴瘤 (DLBCL) 的研究 (粉色：BCL-6 配体 (HY-179317)；蓝色：CRBN 配体 (HY-179305)；黑色：连接子)。

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BCL6-760

BCL6-760 Chemical Structure

CAS No. : 3084696-50-1

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BCL6-760 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker)[1].

体外研究
(In Vitro)

BCL6-760 抑制 OCI-LY-1 细胞生长的 GI50 值为 1.3 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BCL6-760 相关抗体:
体内研究
(In Vivo)

BCL6-760 (15-60 mg/kg，口服，每日一次或两次，连续 5 天) 能有效且持续地降解肿瘤中的 BCL6 蛋白，并在 OCI-LY-1 肿瘤异种移植小鼠模型中产生显著的抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

715.24

Formula

C36H43ClN10O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BCL6-760 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCL6-7603084696-50-1PROTACsBCL6B-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51English ExplanationProteolysis-Targeting ChimeraStructure-Activity RelationshipInhibitorinhibitorinhibit

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目录号：
HY-178777
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