2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. REV-ERB
  4. BE2012

BE2012 是 SR8278 (HY-14415) 的衍生物，是一种强效且选择性的 REV-ERBα/β 拮抗剂，其 EC50 值分别为 0.285 μM 和 0.346 μM。BE2012 与 REV-ERB 的配体结合域 (LBD) 结合，阻止该受体募集共抑制因子，从而解除对下游靶基因的转录抑制。BE2012 可上调急性肌肉损伤小鼠模型中肌源性转录因子 Myf5 和 Myod 的表达，促进肌肉再生和修复。

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BE2012

BE2012 Chemical Structure

CAS No. : 667889-47-6

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BE2012 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels[1].

IC50 & Target[1]

REV-ERBα

0.285 μM (EC50)

REV-ERBβ

0.346 μM (EC50)

分子量

293.36

Formula

C18H19N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BE2012 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BE2012667889-47-6BE 2012BE-2012REV-ERBInhibitorinhibitorinhibit

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产品名称：
BE2012
目录号：
HY-180944
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