2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Bemarituzumab

Bemarituzumab  (Synonyms: 贝玛妥珠单抗)

目录号: HY-P99010 纯度: 99.82%
COA 技术支持

Bemarituzumab 是一种针对 FGFR2b (一种 FGF 受体) 的人源化 IgG1 单克隆抗体。Bemarituzumab 阻止成纤维细胞生长因子结合和激活 FGFR2b。Bemarituzumab 对胃癌和乳腺癌具有抗肿瘤活性。

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CAS No. : 1952272-74-0

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Bemarituzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bemarituzumab is a humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has antitumor activity against gastric and breast cancer[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

FGFR2/CD332
体外研究
(In Vitro)

Bemarituzumab ( 0.001-100 μg/mL，30 min) 以浓度依赖性方式抑制 SNU-16 人胃癌细胞中 FGF7 诱导的 FGFR2 磷酸化和细胞增殖，在 ≥6.25 μg/mL 时达到最大值[2]。
Bemarituzumab 表现出免疫细胞介导的对过表达 FGFR2b 的肿瘤细胞杀伤作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bemarituzumab 相关抗体:
体内研究
(In Vivo)

Bemarituzumab (1-5 mg/kg；静脉注射；每周两次) 以剂量依赖性方式抑制肿瘤生长，并在 OCUM-2M人胃癌细胞异种移植小鼠模型中导致部分小鼠肿瘤消退[2]。
Bemarituzumab (5 mg/kg；腹腔注射；每周两次) 与 5-fluorouracil (HY-90006) 和 Oxaliplatin (HY-17371) 联合使用，在 OCUM-2M 胃癌异种移植模型中，其肿瘤生长抑制效果优于单药治疗，并且不会增加化疗相关毒性[2]。
Bemarituzumab (10 mg/kg；腹腔注射；每两周一次) 显著降低同基因 4T1 小鼠乳腺肿瘤模型中的肿瘤负荷，募集 NK 细胞，并增加 PD-L1 表达细胞和 CD3 阳性 T 细胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CB17 SCID mice (7-8 weeks old), xenograft model of OCUM-2M human gastric cancer cells[2]
Dosage: 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 3 mg/kg, 5 mg/kg (in PBS)
Administration: Intravenous injection, twice a week
Result: Inhibited tumor growth in a dose-dependent manner.
Inhibited and regressed tumor growth starting from a dose of 1 mg/kg.
Caused complete tumor regression in 1/15 mice at the 1.5 mg/kg and 2 mg/kg doses, 4/15 mice at the 3 mg/kg dose, and 6/15 mice at the 5 mg/kg dose by day 42.
Clinical Trial
基因 ID

2263  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

143.86 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

贝玛妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized FGFR-2 alpha (IIIb) Protein, Human (HEK293, His, HY-P76336) can bind Bemarituzumab. The EC50 for this effect is 5.673 ng/mL.
纯度 & 产品资料

纯度: 99.82%

COA (267 KB) SDS-PAGE (70 KB) SEC-HPLC (121 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Bemarituzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bemarituzumab1952272-74-0贝玛妥珠单抗FGFRFibroblast growth factor receptorfirst-in-classhumanized IgG1 monoclonal antibodanticancermammary tumorInhibitorinhibitorinhibit

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