1. Apoptosis Immunology/Inflammation
  2. TNF Receptor Interleukin Related
  3. Benzo-17R-RvD2

Benzo-17R-RvD2 (Benzo-17R-Resolvin D2) 是 RvD2 (HY-121636) 的含苯并类似物。Benzo-17R-RvD2 可增强人巨噬细胞的吞噬作用,限制中性粒细胞浸润,降低 TNF-α 水平,并增加腹膜炎中 IL-1 受体拮抗剂的活性。Benzo-17R-RvD2 可促进人白细胞杀灭大肠杆菌,并减少中性粒细胞聚集面积,且不影响其抗念珠菌活性。Benzo-17R-RvD2 可激活人 RvD2 受体,EC50 值约为 1.5 nM。Benzo-17R-RvD2 可用于炎症相关疾病的研究,例如心血管疾病、癌症、神经炎症、疼痛和肌肉再生。

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Benzo-17R-RvD2

Benzo-17R-RvD2 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Benzo-17R-RvD2 (Benzo-17R-Resolvin D2) is a benzo-containing analog of RvD2 (HY-121636). Benzo-17R-RvD2 enhances human macrophage efferocytosis, limits neutrophil infiltration, reduces TNF-α, and increases IL-1 receptor antagonist in peritonitis. Benzo-17R-RvD2 promotes E. coli killing by human leukocytes and reduces neutrophil swarm area without compromising anti-Candida activity. Benzo-17R-RvD2 activates the human-RvD2 receptor with an EC50 ∼1.5 nM. Benzo-17R-RvD2 can be used in research on inflammation-associated diseases such as cardiovascular disease, cancer, neuroinflammation, pain, and muscle regeneration[1].

IC50 & Target[1]

IL-1

 

human-RvD2 receptor

~1.5 nM (EC50)

分子量

374.47

Formula

C22H30O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Benzo-17R-RvD2
目录号:
HY-180109
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