2. MAPK/ERK Pathway
  3. p38 MAPK
  4. Benzo[a]pyrene diol epoxide

Benzo[a]pyrene diol epoxide 是一种存在于烟草烟雾以及环境污染中的致癌物，是多环芳烃 (PAH) 化合物 benzo[a]pyrene (BaP) 的一种代谢物，可诱导食管癌变。Benzo[a]pyrene diol epoxide 已被证明可以诱导 ERKs 和 p38 MAPK 的激活，其标志是 ERKs 和 p38 MAPK 的磷酸化水平增加。

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Benzo[a]pyrene diol epoxide

Benzo[a]pyrene diol epoxide Chemical Structure

CAS No. : 58917-67-2

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规格 价格 是否有货 数量
1 mg ￥2720
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2.5 mg ￥5424
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Benzo[a]pyrene diol epoxide 相关抗体

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • 生物活性

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生物活性

Benzo[a]pyrene diol epoxide is a carcinogen present in tobacco smoke as well as in environmental pollution. Benzo[a]pyrene diol epoxide is a metabolite of benzo[a]pyrene (BaP) , which is polycyclic aromatic hydrocarbon (PAH) . Benzo[a]pyrene diol epoxide induces esophageal carcinogenesis. Benzo[a]pyrene diol epoxide may act to induce activation of ERKs and p38 MAPK marked by an increased level of phosphorylation of both the ERKs and p38 MAPK which corresponds with the increased activation of both kinases as evidenced by increased phsosphorylation of their substrates Elk-1 and ATF-2, respectively.

分子量

302.32

Formula

C20H14O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Benzo[a]pyrene diol epoxide 相关分类

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Keywords:

Benzo[a]pyrene diol epoxide58917-67-2p38 MAPKInhibitorinhibitorinhibit

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