2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Bexmarilimab

Bexmarilimab  (Synonyms: 贝马瑞利单抗; FP-1305)

目录号: HY-P99236 纯度: 95.00%
COA 技术支持

Bexmarilimab (FP-1305) 是一种强效的人源化抗 CLEVER-1 IgG4 抗体，其 IC50 值为 4.51 nM。Bexmarilimab 能够诱导肿瘤相关巨噬细胞从 M2 表型向 M1 免疫表型转换。Bexmarilimab 可以促进抗原呈递和促炎细胞因子的分泌。Bexmarilimab 能诱导 B 细胞和 T 细胞的活化。Bexmarilimab 可用于免疫和癌症的研究，如结直肠癌。

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CAS No. : 2259301-27-2

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规格 价格 是否有货 数量
1 mg ￥1400
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5 mg ￥4200
In-stock
10 mg ￥6000
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100 mg   询价  

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Bexmarilimab 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bexmarilimab (FP-1305) is a potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM. Bexmarilimab is capable of inducing a phenotypic M2 to M1 immune switch of tumor-associated macrophages. Bexmarilimab can promote antigen presentation and pro-inflammatory cytokine secretion. Bexmarilimab can induce B-cell and T-cell activation. Bexmarilimab can be used in researches of immunology and cancer, such as colorectal carcinoma[1][2].

同型

Human IgG4 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

STAB1/stabilin-1/CLEVER-1
体外研究
(In Vitro)

Bexmarilimab (0.1-1 μg/mL) 可抑制 LPS 刺激后 M2 极化的原代巨噬细胞对 acLDL 的摄取，并诱导 TNFα 的分泌[1]。
Bexmarilimab (0.1-100 μg/mL) 不会在全血中诱导显著的细胞因子释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bexmarilimab 相关抗体:
体内研究
(In Vivo)

Bexmarilimab (3-100 mg/kg，静脉注射，单剂量) 在食蟹猴中显示出剂量依赖性的受体占据持续时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[1]
Dosage: 3, 30 and 100 mg/kg
Administration: Intravenously injection, a single dose
Result: Recovered on day 3 for animals dosed at 3 mg/kg and on day 7for animals dosed at 30 mg/kg.
Showed the duration of receptor blockage lasted 20 days at 100 mg/kg.
Clinical Trial
基因 ID

23166  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.22 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

贝马瑞利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料

纯度: 95.00%

COA (265 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Bexmarilimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bexmarilimab2259301-27-2FP-1305贝马瑞利单抗FP1305FP 1305Transmembrane GlycoproteinCLEVERMacrophagesM1M2B-cellT-cellColorectal carcinomaInhibitorinhibitorinhibit

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目录号：
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