2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. BI-8128

BI-8128 是一种强效的 EGFR 抑制剂，对野生型、T790M、C797S、T790M/C797S 和 L858R/T790M/C797S 突变型 EGFR 的 IC50 分别为 12、6.7、22、10 和 3 nM。BI-8128 显著抑制 Ba/F3 和 PC-9 耐药突变细胞增殖。BI-8128 可用于非小细胞肺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

BI-8128

BI-8128 Chemical Structure

CAS No. : 2769714-36-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

BI-8128 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BI-8128 is a potent EGFR inhibitor, with IC50 values of 12, 6.7, 22, 10, and 3 nM against wild-type, T790M, C797S, T790M/C797S, and L858R/T790M/C797S mutant EGFR, respectively. BI-8128 significantly inhibits the proliferation of Ba/F3 and PC-9 drug-resistant mutant cells. BI-8128 is applicable for the research of non-small cell lung cancer[1].

IC50 & Target[1]

EGFR (WT)

12 nM (IC50)

EGFRT790M

6.7 nM (IC50)

EGFRC797S

22 nM (IC50)

EGFRdel19 T790M C797S

10 nM (IC50)

EGFRL858R/T790M/C797S

3 nM (IC50)

体外研究
(In Vitro)

BI-8128 可强效抑制 Ba/F3 del19 EGFR 细胞的增殖 (IC50 = 1.7 nM)，并对其他表达 EGFR 突变体也表现出显著的抗增殖活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BI-8128 相关抗体:
分子量

610.71

Formula

C32H38N10O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BI-8128 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI-81282769714-36-3BI8128BI 8128EGFREpidermal growth factor receptorErbB-1HER1T790M/C797S double mutationC797S EGFRepidermal growth factor receptorL858R/T790M/C797S EGFR kinaseWT EGFR kinaseATP-binding siteBa/F3 del19 EGFR cellsWT EGFR-expressing A431 cellsnon-small cell lung cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
BI-8128
目录号：
HY-171884
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z