1. Biology Dictionary
  2. RNA Interference

RNA InterferenceRNA 干扰

释义:

RNA Interference is used to study gene function through gene silencing and is widely applied in genetic screening and pathological research in organisms like plants, fungi, and nematodes. RNA interference (RNAi) induces specific degradation of homologous mRNA through double-stranded RNA (dsRNA). The dsRNA is cleaved into short interfering RNA (siRNA), which is loaded into the RNA-induced silencing complex (RISC), where the antisense strand of siRNA guides the recognition and cleavage of target mRNA, achieving post-transcriptional gene silencing.

RNA 干扰可用于通过基因沉默研究基因功能,广泛应用于植物、真菌、线虫等生物体的基因功能筛选及病理研究。RNA 干扰 (RNAi) 通过双链 RNA (dsRNA) 诱导同源 mRNA 的特异性降解,过程包括 dsRNA 被切割为短干扰 RNA (siRNA), 然后装载到 RNA 诱导沉默复合物 (RISC) 中,在 siRNA 的反义链引导下识别并切割靶标 mRNA,从而实现转录后基因沉默。

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