2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. BJH-60

BJH-60 是一种线粒体复合体 1 (mitochondrial complex 1) 抑制剂。BJH-60 能抑制 A549 细胞线粒体耗氧率，其 IC50 值为 1.9 μM。BJH-60 对磷酸二酯酶 (PDE) 无抑制作用。BJH-60 可用于癌症研究，如乳腺癌。

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BJH-60

BJH-60 Chemical Structure

CAS No. : 3067849-06-0

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BJH-60 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BJH-60 is a mitochondrial complex 1 inhibitor. BJH-60 can inhibit mitochondrial oxygen consumption rate with an IC50 of 1.9 μM in A549 cells. BJH-60 shows no PDE inhibitory effect. BJH-60 can be used for the research of cancer, such as breast cancer[1].

体外研究
(In Vitro)

BJH-60 (3-100 μM, 96 h) 可抑制 A549 和 EO771 细胞的增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BJH-60 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549 and EO771 cells
Concentration: 3, 10 and 100 μM
Incubation Time: 96 h
Result: Significantly reduced cell numbers at 100 μM.
体内研究
(In Vivo)

BJH-60 (disodium phosphate produrg) (2 mg/kg；静脉注射；XRT 前 1 小时) 对小鼠 EO771 乳腺肿瘤具有放射增敏作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6 bearing EO771 mammary gland tumors[1]
Dosage: 2 mg/kg
Administration: IV; 1 hour before XRT
Result: Doubled the tumor growth delay to 4 days.
分子量

355.43

Formula

C24H21NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BJH-60 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BJH-603067849-06-0BJH60BJH 60Mitochondrial Metabolismmitochondrial complexoxygen consumptionA549PDEEO771breast cancerInhibitorinhibitorinhibit

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目录号：
HY-178986
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