2. Anti-infection
  3. Parasite
  4. BL-1005

BL-1005 (BS2463)，2 - 噻吩基嘧啶 (TTP)，是一种强效的曼氏血吸虫 (Schistosoma mansoni) 麻痹剂，其 EC50 值为 37 nM。BL-1005 对 HEK293、HeLa 和 HepG2 细胞的细胞毒性较低，CC50 值均大于 20 μM。BL-1005 可导致成年和幼年曼氏血吸虫 (S. mansoni) 麻痹。BL-1005 可用于感染研究。

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BL-1005

BL-1005 Chemical Structure

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BL-1005 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC50 of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC50 >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection[1].

体外研究
(In Vitro)

BL-1005 (0.02-50 μM；48 h) 降低 HEK293，HeLa 和 HepG2 细胞活力，其 CC50 值为 37.3，21.3 和 22.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BL-1005 相关抗体:
体内研究
(In Vivo)

BL-1005 (0.6-1.2 μM; 2 h) 会导致成年和幼年曼氏血吸虫持续麻痹[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Schistosoma mansoni (adult and juvenile, 28-42-day-old)[1]
Dosage: 0.6 μM, 1.2 μM
Administration: 2 h
Result: Induced a sustained paralysis in both adult and juvenile S. mansoni, with partial recovery of motility over 9 days.
分子量

422.88

Formula

C19H17ClF2N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BL-1005 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BL-1005BS2463BL1005BL 1005BS 2463BS-2463ParasiteSchistosoma mansoni,HEK293,HeLa,HepG2
Inhibitorinhibitorinhibit

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产品名称：
BL-1005
目录号：
HY-179116
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