1. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  2. PPAR
  3. BM 170249

BM 170249 是一种过氧化物酶体 (peroxisome) 增殖剂,尤其是在肝腺泡的中央静脉周围区。BM 170249 显著降低大鼠血清中的甘油三酯和胆固醇水平。BM 170249 强力诱导过氧化物酶体脂肪酸 β-氧化系统的关键酶 (如酰基辅酶 A 氧化酶 AOX、多功能酶 PH、硫解酶 PT) 的活性,但导致过氧化物酶体组分中过氧化氢酶和尿酸氧化酶的活性降低。BM 170249 可用于降血脂研究。

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BM 170249

BM 170249 Chemical Structure

CAS No. : 153655-35-7

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生物活性

BM 170249 is a peroxisome proliferator, particularly in the perivenous region of the central acini in the liver. BM 170249 significantly reduces serum triglyceride and cholesterol levels in rats. BM 170249 strongly induces the activity of key enzymes in the peroxisome fatty acid β-oxidation system (such as acyl-CoA oxidase AOX, multifunctional enzyme PH, and thiolase PT), but leads to decreased activity of catalase and uricase in peroxisome components. BM 170249 could be used in lipid-lowering studies[1].

分子量

396.13

Formula

C14H22Cl4O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BM 170249
目录号:
HY-19227
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