2. GPCR/G Protein
  3. GHSR
  4. BMS-317180

BMS-317180 是一种口服有效且强效的生长激素分泌素受体 (GHS-R) 激动剂 (EC50=7.9 nM)。BMS-317180 能刺激体内生长激素 (GH) 的释放。BMS-317180 有望用于老年性衰弱、骨质疏松及癌症恶病质的研究。

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BMS-317180

BMS-317180 Chemical Structure

CAS No. : 295337-71-2

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BMS-317180 相关抗体

Top Publications Citing Use of Products

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GHSR1a

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-317180 is an orally active and potent growth hormone secretagogue receptor (GHS-R) agonist (EC50=7.9 nM). BMS-317180 stimulates endogenous growth hormone (GH) release. BMS-317180 is promising for research of age-related frailty, osteoporosis, and cancer cachexia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
H4 EC50
1.9 nM
Compound: 2, BMS-317180
Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay
Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay
[PMID: 17973363]
H4 EC50
1.9 nM
Compound: 4, BMS-317180
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay
[PMID: 18378446]
分子量

463.53

Formula

C21H33N7O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-317180 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-317180295337-71-2BMS317180BMS 317180GHSRGrowth hormone secretagogue receptorGhrelin receptororally activeGHS-Rcancer cachexiaInhibitorinhibitorinhibit

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产品名称：
BMS-317180
目录号：
HY-119125
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